The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

Abstract Stress during gestation has harmful effects on pregnancy outcome and can lead to spontaneous abortion. Few studies, however, have addressed the impact of gestational stress, particularly auditory stress, on behavioural performance and pregnancy outcome in mice. This study aimed to examine t...

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Autores principales:	Zahra Jafari, Jamshid Faraji, Behroo Mirza Agha, Gerlinde A. S. Metz, Bryan E. Kolb, Majid H. Mohajerani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed778b76fad243ce9eb9a19ab3cdda65
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spelling	oai:doaj.org-article:ed778b76fad243ce9eb9a19ab3cdda652021-12-02T15:06:18ZThe Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour10.1038/s41598-017-04943-82045-2322https://doaj.org/article/ed778b76fad243ce9eb9a19ab3cdda652017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04943-8https://doaj.org/toc/2045-2322Abstract Stress during gestation has harmful effects on pregnancy outcome and can lead to spontaneous abortion. Few studies, however, have addressed the impact of gestational stress, particularly auditory stress, on behavioural performance and pregnancy outcome in mice. This study aimed to examine the effect of two types of gestational stress on uterus receptivity and behavioural performance. Pregnant C57BL/6 mice were randomly assigned to either auditory or physical stress conditions or a control condition from gestational days 12–16. The auditory stress regimen used loud 3000 Hz tone, while the physical stressor consisted of restraint and exposure to an elevated platform. Three behavioural tests were performed in the dams after weaning. Uterine receptivity was investigated by counting the number of sites of implantation and fetal resorption. Also, the offspring survival rates during the early postnatal period were calculated. Auditory stress caused an increase in anxiety-like behaviour, reduced time spent exploring new object/environment, and reduced balance when compared to the physical stress and control groups. Auditory stress also caused higher rates of resorbed embryos and reduction of litter size. Our results suggest that the adverse effect of noise stress is stronger than physical stress for both uterus receptivity and behavioural performance of the dams.Zahra JafariJamshid FarajiBehroo Mirza AghaGerlinde A. S. MetzBryan E. KolbMajid H. MohajeraniNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zahra Jafari Jamshid Faraji Behroo Mirza Agha Gerlinde A. S. Metz Bryan E. Kolb Majid H. Mohajerani The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
description	Abstract Stress during gestation has harmful effects on pregnancy outcome and can lead to spontaneous abortion. Few studies, however, have addressed the impact of gestational stress, particularly auditory stress, on behavioural performance and pregnancy outcome in mice. This study aimed to examine the effect of two types of gestational stress on uterus receptivity and behavioural performance. Pregnant C57BL/6 mice were randomly assigned to either auditory or physical stress conditions or a control condition from gestational days 12–16. The auditory stress regimen used loud 3000 Hz tone, while the physical stressor consisted of restraint and exposure to an elevated platform. Three behavioural tests were performed in the dams after weaning. Uterine receptivity was investigated by counting the number of sites of implantation and fetal resorption. Also, the offspring survival rates during the early postnatal period were calculated. Auditory stress caused an increase in anxiety-like behaviour, reduced time spent exploring new object/environment, and reduced balance when compared to the physical stress and control groups. Auditory stress also caused higher rates of resorbed embryos and reduction of litter size. Our results suggest that the adverse effect of noise stress is stronger than physical stress for both uterus receptivity and behavioural performance of the dams.
format	article
author	Zahra Jafari Jamshid Faraji Behroo Mirza Agha Gerlinde A. S. Metz Bryan E. Kolb Majid H. Mohajerani
author_facet	Zahra Jafari Jamshid Faraji Behroo Mirza Agha Gerlinde A. S. Metz Bryan E. Kolb Majid H. Mohajerani
author_sort	Zahra Jafari
title	The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
title_short	The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
title_full	The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
title_fullStr	The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
title_full_unstemmed	The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour
title_sort	adverse effects of auditory stress on mouse uterus receptivity and behaviour
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed778b76fad243ce9eb9a19ab3cdda65
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The Adverse Effects of Auditory Stress on Mouse Uterus Receptivity and Behaviour

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