Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic

Background: In response to the goal of the World Health Organisation to eliminate hepatitis C virus infections by 2030, Romania is striving for national elimination. An already successful micro-elimination project was expanded to test-and-treat specific populations and at-risk groups. The aim of thi...

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Autores principales:	Anca Elena Butaru, Dan Ionuț Gheonea, Ion Rogoveanu, Mircea Diculescu, Ancuța-Ramona Boicea, Marius Bunescu, Costin-Teodor Streba, Carmen Nicoleta Oancea
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	hepatitis C viral infection micro-elimination screening target linkage to care Medicine R
Acceso en línea:	https://doaj.org/article/ed789730728545b79fd4ab3b4fd46948
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spelling	oai:doaj.org-article:ed789730728545b79fd4ab3b4fd469482021-11-11T17:36:29ZMicro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic10.3390/jcm102149762077-0383https://doaj.org/article/ed789730728545b79fd4ab3b4fd469482021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/4976https://doaj.org/toc/2077-0383Background: In response to the goal of the World Health Organisation to eliminate hepatitis C virus infections by 2030, Romania is striving for national elimination. An already successful micro-elimination project was expanded to test-and-treat specific populations and at-risk groups. The aim of this project was to identify the individuals with HCV infection in disadvantaged regions who do not have proper medical care access. Materials and Methods: Our two-arm interventional cross-sectional study used rapid anti-HCV antibody testing on two population groups from the Romanian southwestern region of Oltenia, approached between September 2020 and May 2021. The first group consisted of predominantly over 40 years old individuals, recruited through five family doctors from two medium-sized towns (community lot—CL). We approached a second group, aged 18–65, through 11 medical offices of five large factories in the same region (industry lot, IL). A 12-items questionnaire was given to each participant, to determine risk factors and record demographic data. Eligible patients initiated antiviral therapy using direct-acting antivirals (DAAs). Results: We enrolled 15,383 individuals between all 16 locations. The overall prevalence by antibody testing was 0.77% (119 cases). Of these, 57 subsequently received treatment with DAAs. We identified blood transfusions as a risk factor within the CL. Participants in the IL reported a relatively high risk for the following situations: sharing of personal hygiene belongings with another person, performing previous blood transfusions, dental interventions and previous surgery. Conclusions: In this global context, the use of micro-elimination allows interventions to be faster and more efficient. This is possible by targeting smaller and specific HCV risk groups.Anca Elena ButaruDan Ionuț GheoneaIon RogoveanuMircea DiculescuAncuța-Ramona BoiceaMarius BunescuCostin-Teodor StrebaCarmen Nicoleta OanceaMDPI AGarticlehepatitis C viral infectionmicro-eliminationscreeningtargetlinkage to careMedicineRENJournal of Clinical Medicine, Vol 10, Iss 4976, p 4976 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatitis C viral infection micro-elimination screening target linkage to care Medicine R
spellingShingle	hepatitis C viral infection micro-elimination screening target linkage to care Medicine R Anca Elena Butaru Dan Ionuț Gheonea Ion Rogoveanu Mircea Diculescu Ancuța-Ramona Boicea Marius Bunescu Costin-Teodor Streba Carmen Nicoleta Oancea Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
description	Background: In response to the goal of the World Health Organisation to eliminate hepatitis C virus infections by 2030, Romania is striving for national elimination. An already successful micro-elimination project was expanded to test-and-treat specific populations and at-risk groups. The aim of this project was to identify the individuals with HCV infection in disadvantaged regions who do not have proper medical care access. Materials and Methods: Our two-arm interventional cross-sectional study used rapid anti-HCV antibody testing on two population groups from the Romanian southwestern region of Oltenia, approached between September 2020 and May 2021. The first group consisted of predominantly over 40 years old individuals, recruited through five family doctors from two medium-sized towns (community lot—CL). We approached a second group, aged 18–65, through 11 medical offices of five large factories in the same region (industry lot, IL). A 12-items questionnaire was given to each participant, to determine risk factors and record demographic data. Eligible patients initiated antiviral therapy using direct-acting antivirals (DAAs). Results: We enrolled 15,383 individuals between all 16 locations. The overall prevalence by antibody testing was 0.77% (119 cases). Of these, 57 subsequently received treatment with DAAs. We identified blood transfusions as a risk factor within the CL. Participants in the IL reported a relatively high risk for the following situations: sharing of personal hygiene belongings with another person, performing previous blood transfusions, dental interventions and previous surgery. Conclusions: In this global context, the use of micro-elimination allows interventions to be faster and more efficient. This is possible by targeting smaller and specific HCV risk groups.
format	article
author	Anca Elena Butaru Dan Ionuț Gheonea Ion Rogoveanu Mircea Diculescu Ancuța-Ramona Boicea Marius Bunescu Costin-Teodor Streba Carmen Nicoleta Oancea
author_facet	Anca Elena Butaru Dan Ionuț Gheonea Ion Rogoveanu Mircea Diculescu Ancuța-Ramona Boicea Marius Bunescu Costin-Teodor Streba Carmen Nicoleta Oancea
author_sort	Anca Elena Butaru
title	Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
title_short	Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
title_full	Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
title_fullStr	Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
title_full_unstemmed	Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic
title_sort	micro-elimination: updated pathway to global elimination of hepatitis c in small communities and industrial settings during the covid 19 pandemic
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed789730728545b79fd4ab3b4fd46948
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Micro-Elimination: Updated Pathway to Global Elimination of Hepatitis C in Small Communities and Industrial Settings during the COVID 19 Pandemic

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