Association of changes in lipid levels with changes in vitamin D levels in a real-world setting

Abstract In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association betwe...

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Autores principales:	Yonghong Li, Carmen H. Tong, Charles M. Rowland, Jeff Radcliff, Lance A. Bare, Michael J. McPhaul, James J. Devlin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed7960aae9ab42d6a46c5c4a46bf9005
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spelling	oai:doaj.org-article:ed7960aae9ab42d6a46c5c4a46bf90052021-11-08T10:54:40ZAssociation of changes in lipid levels with changes in vitamin D levels in a real-world setting10.1038/s41598-021-01064-12045-2322https://doaj.org/article/ed7960aae9ab42d6a46c5c4a46bf90052021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01064-1https://doaj.org/toc/2045-2322Abstract In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.Yonghong LiCarmen H. TongCharles M. RowlandJeff RadcliffLance A. BareMichael J. McPhaulJames J. DevlinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yonghong Li Carmen H. Tong Charles M. Rowland Jeff Radcliff Lance A. Bare Michael J. McPhaul James J. Devlin Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
description	Abstract In clinical trials, vitamin D supplementation has been reported to reduce serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) but not high-density lipoprotein cholesterol (HDL-C). In this cohort study we evaluated the association between changes in vitamin D (25-hydroxyvitamin D) and changes in lipid levels in a real-world setting. Changes in lipid levels over a 1-year period were evaluated among individuals whose vitamin D levels increased (group 1) or decreased (group 2) by ≥ 10 ng/mL in year 2018 versus 2017 (cohort 1; n = 5580), in 2019 versus 2018 (cohort 2, n = 6057), or in 2020 versus 2019 (cohort 3, n = 7249). In each cohort, levels of TC, LDL-C, and TG decreased in group 1 and increased in group 2. Between-group differences in average changes in the 3 cohorts ranged from 10.71 to 12.02 mg/dL for TC, from 7.42 to 8.95 mg/dL for LDL-C, and from 21.59 to 28.09 mg/dL for TG. These differences were significant after adjusting for age, sex, race, education, body mass index, blood pressure, smoking status, geographical location, and baseline levels of vitamin D and lipids (P < 0.001). Changes in vitamin D levels were not significantly associated with changes in HDL-C levels.
format	article
author	Yonghong Li Carmen H. Tong Charles M. Rowland Jeff Radcliff Lance A. Bare Michael J. McPhaul James J. Devlin
author_facet	Yonghong Li Carmen H. Tong Charles M. Rowland Jeff Radcliff Lance A. Bare Michael J. McPhaul James J. Devlin
author_sort	Yonghong Li
title	Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
title_short	Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
title_full	Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
title_fullStr	Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
title_full_unstemmed	Association of changes in lipid levels with changes in vitamin D levels in a real-world setting
title_sort	association of changes in lipid levels with changes in vitamin d levels in a real-world setting
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed7960aae9ab42d6a46c5c4a46bf9005
work_keys_str_mv	AT yonghongli associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT carmenhtong associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT charlesmrowland associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT jeffradcliff associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT lanceabare associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT michaeljmcphaul associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting AT jamesjdevlin associationofchangesinlipidlevelswithchangesinvitamindlevelsinarealworldsetting
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Association of changes in lipid levels with changes in vitamin D levels in a real-world setting

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