Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

Armin Salek Maghsoudi,1,2,* Shokoufeh Hassani,1,2,* Kayvan Mirnia,3 Mohammad Abdollahi1,2 1Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; 2Department of Toxicol...

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Autores principales:	Salek Maghsoudi A, Hassani S, Mirnia K, Abdollahi M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	biosensors heavy metals toxicity nanomaterials review Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ed7d089d945b4e27a7ee3646ebac8d48
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spelling	oai:doaj.org-article:ed7d089d945b4e27a7ee3646ebac8d482021-12-02T16:06:11ZRecent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium1178-2013https://doaj.org/article/ed7d089d945b4e27a7ee3646ebac8d482021-02-01T00:00:00Zhttps://www.dovepress.com/recent-advances-in-nanotechnology-based-biosensors-development-for-det-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Armin Salek Maghsoudi,1,2,* Shokoufeh Hassani,1,2,* Kayvan Mirnia,3 Mohammad Abdollahi1,2 1Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; 2Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Neonatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran*These authors contributed equally to this workCorrespondence: Mohammad AbdollahiFaculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, IranTel +98 21 64122319Email mohammad@tums.ac.irAbstract: Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards in humans’ health. To achieve rapid, high-sensitivity methods for analyzing ultra-trace amounts of heavy metals in different environmental and biological samples, novel biosensors have been designed with the participation of strategies applied in nanotechnology. This review attempted to investigate the novel, sensitive, efficient, cost-benefit, point of care, and user-friendly biosensors designed to detect these heavy metals based on functional mechanisms. The study’s search strategies included examining the primary databases from 2015 onwards and various keywords focusing on heavy metal biosensors’ performance and toxicity mechanisms. The use of aptamers and whole cells as two important bio-functional nanomaterials is remarkable in heavy metal diagnostic biosensors’ bioreceptor design. The application of hybridized nanomaterials containing a specific physicochemical function in the presence of a suitable transducer can improve the sensing performance to achieve an integrated detection system. Our study showed that in addition to both labeled and label-free detection strategies, a wide range of nanoparticles and nanocomposites were used to modify the biosensor surface platform in the detection of heavy metals. The detection limit and linear dynamic range as an essential characteristic of superior biosensors for the primary toxic metals are studied. Furthermore, the perspectives and challenges facing the design of heavy metal biosensors are outlined. The development of novel biosensors and the application of nanotechnology, especially in real samples, face challenges such as the capability to simultaneously detect multiple heavy metals, the interference process in complex matrices, the efficiency and stability of nanomaterials implemented in various laboratory conditions.Keywords: biosensors, heavy metals, toxicity, nanomaterials, reviewSalek Maghsoudi AHassani SMirnia KAbdollahi MDove Medical Pressarticlebiosensorsheavy metalstoxicitynanomaterialsreviewMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 803-832 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biosensors heavy metals toxicity nanomaterials review Medicine (General) R5-920
spellingShingle	biosensors heavy metals toxicity nanomaterials review Medicine (General) R5-920 Salek Maghsoudi A Hassani S Mirnia K Abdollahi M Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
description	Armin Salek Maghsoudi,1,2,* Shokoufeh Hassani,1,2,* Kayvan Mirnia,3 Mohammad Abdollahi1,2 1Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran; 2Department of Toxicology and Pharmacology, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran; 3Department of Neonatology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran*These authors contributed equally to this workCorrespondence: Mohammad AbdollahiFaculty of Pharmacy and The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences (TUMS), Tehran, IranTel +98 21 64122319Email mohammad@tums.ac.irAbstract: Heavy metals cause considerable environmental pollution due to their extent and non-degradability in the environment. Analysis and trace levels of arsenic, lead, mercury, and cadmium as the most toxic heavy metals show that they can cause various hazards in humans’ health. To achieve rapid, high-sensitivity methods for analyzing ultra-trace amounts of heavy metals in different environmental and biological samples, novel biosensors have been designed with the participation of strategies applied in nanotechnology. This review attempted to investigate the novel, sensitive, efficient, cost-benefit, point of care, and user-friendly biosensors designed to detect these heavy metals based on functional mechanisms. The study’s search strategies included examining the primary databases from 2015 onwards and various keywords focusing on heavy metal biosensors’ performance and toxicity mechanisms. The use of aptamers and whole cells as two important bio-functional nanomaterials is remarkable in heavy metal diagnostic biosensors’ bioreceptor design. The application of hybridized nanomaterials containing a specific physicochemical function in the presence of a suitable transducer can improve the sensing performance to achieve an integrated detection system. Our study showed that in addition to both labeled and label-free detection strategies, a wide range of nanoparticles and nanocomposites were used to modify the biosensor surface platform in the detection of heavy metals. The detection limit and linear dynamic range as an essential characteristic of superior biosensors for the primary toxic metals are studied. Furthermore, the perspectives and challenges facing the design of heavy metal biosensors are outlined. The development of novel biosensors and the application of nanotechnology, especially in real samples, face challenges such as the capability to simultaneously detect multiple heavy metals, the interference process in complex matrices, the efficiency and stability of nanomaterials implemented in various laboratory conditions.Keywords: biosensors, heavy metals, toxicity, nanomaterials, review
format	article
author	Salek Maghsoudi A Hassani S Mirnia K Abdollahi M
author_facet	Salek Maghsoudi A Hassani S Mirnia K Abdollahi M
author_sort	Salek Maghsoudi A
title	Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
title_short	Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
title_full	Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
title_fullStr	Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
title_full_unstemmed	Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium
title_sort	recent advances in nanotechnology-based biosensors development for detection of arsenic, lead, mercury, and cadmium
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/ed7d089d945b4e27a7ee3646ebac8d48
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Recent Advances in Nanotechnology-Based Biosensors Development for Detection of Arsenic, Lead, Mercury, and Cadmium

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