Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience

Deborah Taira Juarez, Kendra M Demaris, Roy Goo, Christina Louise Mnatzaganian, Helen Wong SmithDaniel K Inouye College of Pharmacy, University of Hawaii at Hilo, Honolulu, HI, USAAbstract: The 2014 American Diabetes Association guidelines denote four means of diagnosing diabetes. The first of thes...

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Autores principales:	Juarez DT, Demaris KM, Goo R, Mnatzaganian CL, Wong Smith H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/ed7d53de2a0a409698667cb8485d9ae8
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spelling	oai:doaj.org-article:ed7d53de2a0a409698667cb8485d9ae82021-12-02T07:23:14ZSignificance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience1178-7007https://doaj.org/article/ed7d53de2a0a409698667cb8485d9ae82014-10-01T00:00:00Zhttp://www.dovepress.com/significance-of-hba1c-and-its-measurement-in-the-diagnosis-of-diabetes-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Deborah Taira Juarez, Kendra M Demaris, Roy Goo, Christina Louise Mnatzaganian, Helen Wong SmithDaniel K Inouye College of Pharmacy, University of Hawaii at Hilo, Honolulu, HI, USAAbstract: The 2014 American Diabetes Association guidelines denote four means of diagnosing diabetes. The first of these is a glycosylated hemoglobin (HbA1c) >6.5%. This literature review summarizes studies (n=47) in the USA examining the significance, strengths, and limitations of using HbA1c as a diagnostic tool for diabetes, relative to other available means. Due to the relatively recent adoption of HbA1c as a diabetes mellitus diagnostic tool, a hybrid systematic, truncated review of the literature was implemented. Based on these studies, we conclude that HbA1c screening for diabetes has been found to be convenient and effective in diagnosing diabetes. HbA1c screening is particularly helpful in community-based and acute care settings where tests requiring fasting are not practical. Using HbA1c to diagnose diabetes also has some limitations. For instance, HbA1c testing may underestimate the prevalence of diabetes, particularly among whites. Because this bias differs by racial group, prevalence and resulting estimates of health disparities based on HbA1c screening differ from those based on other methods of diagnosis. In addition, existing evidence suggests that HbA1c screening may not be valid in certain subgroups, such as children, women with gestational diabetes, patients with human immunodeficiency virus, and those with prediabetes. Further guidelines are needed to clarify the appropriate use of HbA1c screening in these populations.Keywords: diabetes mellitus, diagnosis, glycosylated hemoglobin, USAJuarez DTDemaris KMGoo RMnatzaganian CLWong Smith HDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2014, Iss default, Pp 487-494 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Juarez DT Demaris KM Goo R Mnatzaganian CL Wong Smith H Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
description	Deborah Taira Juarez, Kendra M Demaris, Roy Goo, Christina Louise Mnatzaganian, Helen Wong SmithDaniel K Inouye College of Pharmacy, University of Hawaii at Hilo, Honolulu, HI, USAAbstract: The 2014 American Diabetes Association guidelines denote four means of diagnosing diabetes. The first of these is a glycosylated hemoglobin (HbA1c) >6.5%. This literature review summarizes studies (n=47) in the USA examining the significance, strengths, and limitations of using HbA1c as a diagnostic tool for diabetes, relative to other available means. Due to the relatively recent adoption of HbA1c as a diabetes mellitus diagnostic tool, a hybrid systematic, truncated review of the literature was implemented. Based on these studies, we conclude that HbA1c screening for diabetes has been found to be convenient and effective in diagnosing diabetes. HbA1c screening is particularly helpful in community-based and acute care settings where tests requiring fasting are not practical. Using HbA1c to diagnose diabetes also has some limitations. For instance, HbA1c testing may underestimate the prevalence of diabetes, particularly among whites. Because this bias differs by racial group, prevalence and resulting estimates of health disparities based on HbA1c screening differ from those based on other methods of diagnosis. In addition, existing evidence suggests that HbA1c screening may not be valid in certain subgroups, such as children, women with gestational diabetes, patients with human immunodeficiency virus, and those with prediabetes. Further guidelines are needed to clarify the appropriate use of HbA1c screening in these populations.Keywords: diabetes mellitus, diagnosis, glycosylated hemoglobin, USA
format	article
author	Juarez DT Demaris KM Goo R Mnatzaganian CL Wong Smith H
author_facet	Juarez DT Demaris KM Goo R Mnatzaganian CL Wong Smith H
author_sort	Juarez DT
title	Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
title_short	Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
title_full	Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
title_fullStr	Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
title_full_unstemmed	Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience
title_sort	significance of hba1c and its measurement in the diagnosis of diabetes mellitus: us experience
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/ed7d53de2a0a409698667cb8485d9ae8
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Significance of HbA1c and its measurement in the diagnosis of diabetes mellitus: US experience

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