A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and p...

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Autores principales: Sandhya Bangaru, Heng Zhang, Iuliia M. Gilchuk, Thomas G. Voss, Ryan P. Irving, Pavlo Gilchuk, Pranathi Matta, Xueyong Zhu, Shanshan Lang, Travis Nieusma, Juergen A. Richt, Randy A. Albrecht, Hillary A. Vanderven, Robin Bombardi, Stephen J. Kent, Andrew B. Ward, Ian A. Wilson, James E. Crowe
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Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ed7f5c4471db479d99f688c74abaa776
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spelling oai:doaj.org-article:ed7f5c4471db479d99f688c74abaa7762021-12-02T14:38:51ZA multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA10.1038/s41467-018-04704-92041-1723https://doaj.org/article/ed7f5c4471db479d99f688c74abaa7762018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04704-9https://doaj.org/toc/2041-1723Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease.Sandhya BangaruHeng ZhangIuliia M. GilchukThomas G. VossRyan P. IrvingPavlo GilchukPranathi MattaXueyong ZhuShanshan LangTravis NieusmaJuergen A. RichtRandy A. AlbrechtHillary A. VandervenRobin BombardiStephen J. KentAndrew B. WardIan A. WilsonJames E. CroweNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sandhya Bangaru
Heng Zhang
Iuliia M. Gilchuk
Thomas G. Voss
Ryan P. Irving
Pavlo Gilchuk
Pranathi Matta
Xueyong Zhu
Shanshan Lang
Travis Nieusma
Juergen A. Richt
Randy A. Albrecht
Hillary A. Vanderven
Robin Bombardi
Stephen J. Kent
Andrew B. Ward
Ian A. Wilson
James E. Crowe
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
description Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and protects mice from disease.
format article
author Sandhya Bangaru
Heng Zhang
Iuliia M. Gilchuk
Thomas G. Voss
Ryan P. Irving
Pavlo Gilchuk
Pranathi Matta
Xueyong Zhu
Shanshan Lang
Travis Nieusma
Juergen A. Richt
Randy A. Albrecht
Hillary A. Vanderven
Robin Bombardi
Stephen J. Kent
Andrew B. Ward
Ian A. Wilson
James E. Crowe
author_facet Sandhya Bangaru
Heng Zhang
Iuliia M. Gilchuk
Thomas G. Voss
Ryan P. Irving
Pavlo Gilchuk
Pranathi Matta
Xueyong Zhu
Shanshan Lang
Travis Nieusma
Juergen A. Richt
Randy A. Albrecht
Hillary A. Vanderven
Robin Bombardi
Stephen J. Kent
Andrew B. Ward
Ian A. Wilson
James E. Crowe
author_sort Sandhya Bangaru
title A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
title_short A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
title_full A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
title_fullStr A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
title_full_unstemmed A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
title_sort multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza ha
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ed7f5c4471db479d99f688c74abaa776
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