Laxative Effects of a Standardized Extract of Dendropanax morbiferus H. Léveille Leaves on Experimental Constipation in Rats

Background and Objectives: This study aimed at investigating the laxative effects of a standardized aqueous extract of Dendropanax morbiferus H. Lév. on two different constipation rat models. Materials and Methods: Animal studies were conducte...

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Autores principales:	Ju-Ryun Na, Ki Hoon Lee, Eun Kim, Kwontack Hwang, Chang-Su Na, Sunoh Kim
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Dendropanax morbiferus</i> H. Lév. constipation laxative effect low-fiber diet loperamide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/ed8023e4ea914944a0d02ae2bcaf9707
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spelling	oai:doaj.org-article:ed8023e4ea914944a0d02ae2bcaf97072021-11-25T18:18:04ZLaxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats10.3390/medicina571111471648-91441010-660Xhttps://doaj.org/article/ed8023e4ea914944a0d02ae2bcaf97072021-10-01T00:00:00Zhttps://www.mdpi.com/1648-9144/57/11/1147https://doaj.org/toc/1010-660Xhttps://doaj.org/toc/1648-9144<i>Background and Objectives:</i> This study aimed at investigating the laxative effects of a standardized aqueous extract of <i>Dendropanax morbiferus</i> H. Lév. on two different constipation rat models. <i>Materials and Methods:</i> Animal studies were conducted with low-fiber diet-induced and loperamide-induced constipation animal models, and isolated colons were used in ex vivo analysis to determine the changes in colonic motility caused by <i>D. morbiferus</i> H. Lév. leaf extract (DPL). <i>Results:</i> The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea. The laxative effect of DPL was confirmed to improve the charcoal excretion time upon DPL treatment in a low-fiber diet or loperamide-induced constipation model through gastrointestinal (GI) motility evaluation using the charcoal meal test. In addition, when DPL was administered to RAW264.7 cells and loperamide-induced constipation model rats, the production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) increased significantly in cells and tissue. Furthermore, DPL dose-dependently stimulated the spontaneous contractile amplitude and frequency of the isolated rat colon. <i>Conclusion:</i> Although our study did not provide information on the acute or chronic toxicity of DPL, our results demonstrated that DPL can effectively promote defecation frequency and rat colon contraction, providing scientific evidence to support the use of DPL as a therapeutic application. However, further toxicity studies of DPL are needed prior to the initiation of clinical trials and clinical applications.Ju-Ryun NaKi Hoon LeeEun KimKwontack HwangChang-Su NaSunoh KimMDPI AGarticle<i>Dendropanax morbiferus</i> H. Lév.constipationlaxative effectlow-fiber dietloperamideMedicine (General)R5-920ENMedicina, Vol 57, Iss 1147, p 1147 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Dendropanax morbiferus</i> H. Lév. constipation laxative effect low-fiber diet loperamide Medicine (General) R5-920
spellingShingle	<i>Dendropanax morbiferus</i> H. Lév. constipation laxative effect low-fiber diet loperamide Medicine (General) R5-920 Ju-Ryun Na Ki Hoon Lee Eun Kim Kwontack Hwang Chang-Su Na Sunoh Kim Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
description	<i>Background and Objectives:</i> This study aimed at investigating the laxative effects of a standardized aqueous extract of <i>Dendropanax morbiferus</i> H. Lév. on two different constipation rat models. <i>Materials and Methods:</i> Animal studies were conducted with low-fiber diet-induced and loperamide-induced constipation animal models, and isolated colons were used in ex vivo analysis to determine the changes in colonic motility caused by <i>D. morbiferus</i> H. Lév. leaf extract (DPL). <i>Results:</i> The results showed that DPL administration significantly improved certain reduced fecal parameters (number, weight, and water content of the stools) in a both low-fiber diet and loperamide-induced constipation models without adverse effects of diarrhea. The laxative effect of DPL was confirmed to improve the charcoal excretion time upon DPL treatment in a low-fiber diet or loperamide-induced constipation model through gastrointestinal (GI) motility evaluation using the charcoal meal test. In addition, when DPL was administered to RAW264.7 cells and loperamide-induced constipation model rats, the production of prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) increased significantly in cells and tissue. Furthermore, DPL dose-dependently stimulated the spontaneous contractile amplitude and frequency of the isolated rat colon. <i>Conclusion:</i> Although our study did not provide information on the acute or chronic toxicity of DPL, our results demonstrated that DPL can effectively promote defecation frequency and rat colon contraction, providing scientific evidence to support the use of DPL as a therapeutic application. However, further toxicity studies of DPL are needed prior to the initiation of clinical trials and clinical applications.
format	article
author	Ju-Ryun Na Ki Hoon Lee Eun Kim Kwontack Hwang Chang-Su Na Sunoh Kim
author_facet	Ju-Ryun Na Ki Hoon Lee Eun Kim Kwontack Hwang Chang-Su Na Sunoh Kim
author_sort	Ju-Ryun Na
title	Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
title_short	Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
title_full	Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
title_fullStr	Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
title_full_unstemmed	Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats
title_sort	laxative effects of a standardized extract of <i>dendropanax morbiferus</i> h. léveille leaves on experimental constipation in rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed8023e4ea914944a0d02ae2bcaf9707
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Laxative Effects of a Standardized Extract of <i>Dendropanax morbiferus</i> H. Léveille Leaves on Experimental Constipation in Rats

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