High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon

Abstract Culex mosquitoes particularly Culex quinquefasciatus are important arboviral and filariasis vectors, however despite this important epidemiological role, there is still a paucity of data on their bionomics. The present study was undertaken to assess the insecticide resistance status of Cx....

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Autores principales:	Abdou Talipouo, Konstantinos Mavridis, Elysée Nchoutpouen, Borel Djiappi-Tchamen, Emmanouil Alexandros Fotakis, Edmond Kopya, Roland Bamou, Sévilor Kekeunou, Parfait Awono-Ambene, Vasileia Balabanidou, Sofia Balaska, Charles Sinclair Wondji, John Vontas, Christophe Antonio-Nkondjio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed838575707b4d94bb9bdc7922c1f8d2
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spelling	oai:doaj.org-article:ed838575707b4d94bb9bdc7922c1f8d22021-12-02T14:25:09ZHigh insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon10.1038/s41598-021-86850-72045-2322https://doaj.org/article/ed838575707b4d94bb9bdc7922c1f8d22021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86850-7https://doaj.org/toc/2045-2322Abstract Culex mosquitoes particularly Culex quinquefasciatus are important arboviral and filariasis vectors, however despite this important epidemiological role, there is still a paucity of data on their bionomics. The present study was undertaken to assess the insecticide resistance status of Cx. quinquefasciatus populations from four districts of Yaoundé (Cameroon). All Culex quinquefasciatus populations except one displayed high resistance to bendiocarb and malathion with mortalities ranging from 0 to 89% while high resistance intensity against both permethrin and deltamethrin was recorded. Molecular analyses revealed high frequencies of the ACE-1 G119S mutation (ranging from 0 to 33%) and kdr L1014F allele (ranging from 55 to 74%) in all Cx. quinquefasciatus populations. Significant overexpression was detected for cytochrome P450s genes CYP6AA7 and CYP6Z10, as well as for Esterase A and Esterase B genes. The total cuticular hydrocarbon content, a proxy of cuticular resistance, was significantly increased (compared to the S-lab strain) in one population. The study confirms strong insecticide resistance mediated by different mechanisms in Cx. quinquefasciatus populations from the city of Yaoundé. The expansion of insecticide resistance in Culex populations could affect the effectiveness of current vector control measures and stress the need for the implementation of integrated vector control strategies in urban settings.Abdou TalipouoKonstantinos MavridisElysée NchoutpouenBorel Djiappi-TchamenEmmanouil Alexandros FotakisEdmond KopyaRoland BamouSévilor KekeunouParfait Awono-AmbeneVasileia BalabanidouSofia BalaskaCharles Sinclair WondjiJohn VontasChristophe Antonio-NkondjioNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abdou Talipouo Konstantinos Mavridis Elysée Nchoutpouen Borel Djiappi-Tchamen Emmanouil Alexandros Fotakis Edmond Kopya Roland Bamou Sévilor Kekeunou Parfait Awono-Ambene Vasileia Balabanidou Sofia Balaska Charles Sinclair Wondji John Vontas Christophe Antonio-Nkondjio High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
description	Abstract Culex mosquitoes particularly Culex quinquefasciatus are important arboviral and filariasis vectors, however despite this important epidemiological role, there is still a paucity of data on their bionomics. The present study was undertaken to assess the insecticide resistance status of Cx. quinquefasciatus populations from four districts of Yaoundé (Cameroon). All Culex quinquefasciatus populations except one displayed high resistance to bendiocarb and malathion with mortalities ranging from 0 to 89% while high resistance intensity against both permethrin and deltamethrin was recorded. Molecular analyses revealed high frequencies of the ACE-1 G119S mutation (ranging from 0 to 33%) and kdr L1014F allele (ranging from 55 to 74%) in all Cx. quinquefasciatus populations. Significant overexpression was detected for cytochrome P450s genes CYP6AA7 and CYP6Z10, as well as for Esterase A and Esterase B genes. The total cuticular hydrocarbon content, a proxy of cuticular resistance, was significantly increased (compared to the S-lab strain) in one population. The study confirms strong insecticide resistance mediated by different mechanisms in Cx. quinquefasciatus populations from the city of Yaoundé. The expansion of insecticide resistance in Culex populations could affect the effectiveness of current vector control measures and stress the need for the implementation of integrated vector control strategies in urban settings.
format	article
author	Abdou Talipouo Konstantinos Mavridis Elysée Nchoutpouen Borel Djiappi-Tchamen Emmanouil Alexandros Fotakis Edmond Kopya Roland Bamou Sévilor Kekeunou Parfait Awono-Ambene Vasileia Balabanidou Sofia Balaska Charles Sinclair Wondji John Vontas Christophe Antonio-Nkondjio
author_facet	Abdou Talipouo Konstantinos Mavridis Elysée Nchoutpouen Borel Djiappi-Tchamen Emmanouil Alexandros Fotakis Edmond Kopya Roland Bamou Sévilor Kekeunou Parfait Awono-Ambene Vasileia Balabanidou Sofia Balaska Charles Sinclair Wondji John Vontas Christophe Antonio-Nkondjio
author_sort	Abdou Talipouo
title	High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
title_short	High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
title_full	High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
title_fullStr	High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
title_full_unstemmed	High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon
title_sort	high insecticide resistance mediated by different mechanisms in culex quinquefasciatus populations from the city of yaoundé, cameroon
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed838575707b4d94bb9bdc7922c1f8d2
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High insecticide resistance mediated by different mechanisms in Culex quinquefasciatus populations from the city of Yaoundé, Cameroon

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