Attenuation of a Pathogenic <italic toggle="yes">Mycoplasma</italic> Strain by Modification of the <italic toggle="yes">obg</italic> Gene by Using Synthetic Biology Approaches

Attenuation of a Pathogenic <italic toggle="yes">Mycoplasma</italic> Strain by Modification of the <italic toggle="yes">obg</italic> Gene by Using Synthetic Biology Approaches

ABSTRACT Mycoplasma species are responsible for several economically significant livestock diseases for which there is a need for new and improved vaccines. Most of the existing mycoplasma vaccines are attenuated strains that have been empirically obtained by serial passages or by chemical mutagenes...

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Main Authors: Carole Lartigue, Yanina Valverde Timana, Fabien Labroussaa, Elise Schieck, Anne Liljander, Flavio Sacchini, Horst Posthaus, Brigitte Batailler, Pascal Sirand-Pugnet, Sanjay Vashee, Joerg Jores, Alain Blanchard
Format: article
Language:EN
Published: American Society for Microbiology 2019
Subjects:
GTPase Obg
Mycoplasma
Saccharomyces cerevisiae
attenuated strain
genome engineering
genome transplantation
Microbiology
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Online Access:https://doaj.org/article/ed83cef1f72e4a6fb7a486e1ae7354d3
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https://doaj.org/article/ed83cef1f72e4a6fb7a486e1ae7354d3

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