Cardiac Sarcoidosis: When and How to Treat Inflammation

Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A...

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Autores principales:	Gerard T Giblin, Laura Murphy, Garrick C Stewart, Akshay S Desai, Marcelo F Di Carli, Ron Blankstein, Michael M Givertz, Usha B Tedrow, William H Sauer, Gary M Hunninghake, Paul F Dellaripa, Sanjay Divakaran, Neal K Lakdawala
Formato:	article
Lenguaje:	EN
Publicado:	Radcliffe Medical Media 2021
Materias:	Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/ed85c46b84b54899967bf07123503384
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spelling	oai:doaj.org-article:ed85c46b84b54899967bf071235033842021-12-04T16:05:23ZCardiac Sarcoidosis: When and How to Treat Inflammation10.15420/cfr.2021.162057-75592057-7540https://doaj.org/article/ed85c46b84b54899967bf071235033842021-11-01T00:00:00Zhttps://www.cfrjournal.com/articleindex/cfr.2021.16https://doaj.org/toc/2057-7540https://doaj.org/toc/2057-7559Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A paucity of randomised data exist on who, when and how to treat myocardial inflammation in cardiac sarcoidosis. Despite this, corticosteroids continue to be the mainstay of therapy for the inflammatory phase, with an evolving role for steroid-sparing and biological agents. This review explores the immunopathogenesis of inflammation in sarcoidosis, current evidence-based treatment indications and commonly used immunosuppression agents. It explores a multidisciplinary treatment and monitoring approach to myocardial inflammation and outlines current gaps in our understanding of this condition, emerging research and future directions in this field.Gerard T GiblinLaura MurphyGarrick C StewartAkshay S DesaiMarcelo F Di CarliRon BlanksteinMichael M GivertzUsha B TedrowWilliam H SauerGary M HunninghakePaul F DellaripaSanjay DivakaranNeal K LakdawalaRadcliffe Medical MediaarticleDiseases of the circulatory (Cardiovascular) systemRC666-701ENCardiac Failure Review , Vol 7, Iss , Pp - (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Diseases of the circulatory (Cardiovascular) system RC666-701 Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala Cardiac Sarcoidosis: When and How to Treat Inflammation
description	Sarcoidosis is a complex, multisystem inflammatory disease with a heterogeneous clinical spectrum. Approximately 25% of patients with systemic sarcoidosis will have cardiac involvement that portends a poorer outcome. The diagnosis, particularly of isolated cardiac sarcoidosis, can be challenging. A paucity of randomised data exist on who, when and how to treat myocardial inflammation in cardiac sarcoidosis. Despite this, corticosteroids continue to be the mainstay of therapy for the inflammatory phase, with an evolving role for steroid-sparing and biological agents. This review explores the immunopathogenesis of inflammation in sarcoidosis, current evidence-based treatment indications and commonly used immunosuppression agents. It explores a multidisciplinary treatment and monitoring approach to myocardial inflammation and outlines current gaps in our understanding of this condition, emerging research and future directions in this field.
format	article
author	Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala
author_facet	Gerard T Giblin Laura Murphy Garrick C Stewart Akshay S Desai Marcelo F Di Carli Ron Blankstein Michael M Givertz Usha B Tedrow William H Sauer Gary M Hunninghake Paul F Dellaripa Sanjay Divakaran Neal K Lakdawala
author_sort	Gerard T Giblin
title	Cardiac Sarcoidosis: When and How to Treat Inflammation
title_short	Cardiac Sarcoidosis: When and How to Treat Inflammation
title_full	Cardiac Sarcoidosis: When and How to Treat Inflammation
title_fullStr	Cardiac Sarcoidosis: When and How to Treat Inflammation
title_full_unstemmed	Cardiac Sarcoidosis: When and How to Treat Inflammation
title_sort	cardiac sarcoidosis: when and how to treat inflammation
publisher	Radcliffe Medical Media
publishDate	2021
url	https://doaj.org/article/ed85c46b84b54899967bf07123503384
work_keys_str_mv	AT gerardtgiblin cardiacsarcoidosiswhenandhowtotreatinflammation AT lauramurphy cardiacsarcoidosiswhenandhowtotreatinflammation AT garrickcstewart cardiacsarcoidosiswhenandhowtotreatinflammation AT akshaysdesai cardiacsarcoidosiswhenandhowtotreatinflammation AT marcelofdicarli cardiacsarcoidosiswhenandhowtotreatinflammation AT ronblankstein cardiacsarcoidosiswhenandhowtotreatinflammation AT michaelmgivertz cardiacsarcoidosiswhenandhowtotreatinflammation AT ushabtedrow cardiacsarcoidosiswhenandhowtotreatinflammation AT williamhsauer cardiacsarcoidosiswhenandhowtotreatinflammation AT garymhunninghake cardiacsarcoidosiswhenandhowtotreatinflammation AT paulfdellaripa cardiacsarcoidosiswhenandhowtotreatinflammation AT sanjaydivakaran cardiacsarcoidosiswhenandhowtotreatinflammation AT nealklakdawala cardiacsarcoidosiswhenandhowtotreatinflammation
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Cardiac Sarcoidosis: When and How to Treat Inflammation

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