Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

Evaluation of association of HNF1B variants with diverse cancers: collaborative analysis of data from 19 genome-wide association studies.

<h4>Background</h4>Genome-wide association studies have found type 2 diabetes-associated variants in the HNF1B gene to exhibit reciprocal associations with prostate cancer risk. We aimed to identify whether these variants may have an effect on cancer risk in general versus a specific eff...

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Auteurs principaux: Katherine S Elliott, Eleftheria Zeggini, Mark I McCarthy, Julius Gudmundsson, Patrick Sulem, Simon N Stacey, Steinunn Thorlacius, Laufey Amundadottir, Henrik Grönberg, Jianfeng Xu, Valerie Gaborieau, Rosalind A Eeles, David E Neal, Jenny L Donovan, Freddie C Hamdy, Kenneth Muir, Shih-Jen Hwang, Margaret R Spitz, Brent Zanke, Luis Carvajal-Carmona, Kevin M Brown, Australian Melanoma Family Study Investigators, Nicholas K Hayward, Stuart Macgregor, Ian P M Tomlinson, Mathieu Lemire, Christopher I Amos, Joanne M Murabito, William B Isaacs, Douglas F Easton, Paul Brennan, PanScan Consortium, Rosa B Barkardottir, Daniel F Gudbjartsson, Thorunn Rafnar, David J Hunter, Stephen J Chanock, Kari Stefansson, John P A Ioannidis
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2010
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/ed86bff323304eb0bb405d306b665368
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https://doaj.org/article/ed86bff323304eb0bb405d306b665368

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