Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants

Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants

Young-Taeg SulDepartment of Biomaterials/Handicap Research, Institute for Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, SwedenAbstract: TiO2 nanotubes are fabricated on TiO2 grit-blasted, screw-shaped rough titanium (ASTM grade 4) implants (3.75 × 7 mm) usi...

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Autor principal: Young-Taeg Sul
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Lenguaje:EN
Publicado: Dove Medical Press 2010
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Medicine (General)
R5-920
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spelling oai:doaj.org-article:ed87daeabcfa465c93fe893523a1e8872021-12-02T02:10:27ZElectrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants1176-91141178-2013https://doaj.org/article/ed87daeabcfa465c93fe893523a1e8872010-02-01T00:00:00Zhttp://www.dovepress.com/electrochemical-growth-behavior-surface-properties-and-enhanced-in-viv-a3976https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Young-Taeg SulDepartment of Biomaterials/Handicap Research, Institute for Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, SwedenAbstract: TiO2 nanotubes are fabricated on TiO2 grit-blasted, screw-shaped rough titanium (ASTM grade 4) implants (3.75 × 7 mm) using potentiostatic anodization at 20 V in 1 M H3PO4 + 0.4 wt.% HF. The growth behavior and surface properties of the nanotubes are investigated as a function of the reaction time. The results show that vertically aligned nanotubes of ≈700 nm in length, with highly ordered structures of ≈40 nm spacing and ≈15 nm wall thickness may be grown independent of reaction time. The geometrical properties of nanotubes increase with reaction time (mean pore size, pore size distribution [PSD], and porosity ≈90 nm, ≈40–127 nm and 45%, respectively for 30 minutes; ≈107 nm, ≈63–140 nm and 56% for one hour; ≈108 nm, ≈58–150 nm and 60% for three hours). It is found that the fluorinated chemistry of the nanotubes of F-TiO2, TiOF2, and F-Ti-O with F ion incorporation of ≈5 at.%, and their amorphous structure is the same regardless of the reaction time, while the average roughness (Sa) gradually decreases and the developed surface area (Sdr) slightly increases with reaction time. The results of studies on animals show that, despite their low roughness values, after six weeks the fluorinated TiO2 nanotube implants in rabbit femurs demonstrate significantly increased osseointegration strengths (41 vs 29 Ncm; P = 0.008) and new bone formation (57.5% vs 65.5%; P = 0.008) (n = 8), and reveal more frequently direct bone/cell contact at the bone–implant interface by high-resolution scanning electron microscope observations as compared with the blasted, moderately rough implants that have hitherto been widely used for clinically favorable performance. The results of the animal studies constitute significant evidence that the presence of the nanotubes and the resulting fluorinated surface chemistry determine the nature of the bone responses to the implants. The present in vivo results point to potential applications of the TiO2 nanotubes in the field of bone implants and bone tissue engineering.Keywords: electrochemical fabrication, fluorinated TiO2 nanotubes, surface properties, osseointegrated titanium implant, in vivo bone response Young-Taeg SulDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2010, Iss default, Pp 87-100 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Young-Taeg Sul
Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
description Young-Taeg SulDepartment of Biomaterials/Handicap Research, Institute for Clinical Sciences, Sahlgrenska Academy, Gothenburg University, Gothenburg, SwedenAbstract: TiO2 nanotubes are fabricated on TiO2 grit-blasted, screw-shaped rough titanium (ASTM grade 4) implants (3.75 × 7 mm) using potentiostatic anodization at 20 V in 1 M H3PO4 + 0.4 wt.% HF. The growth behavior and surface properties of the nanotubes are investigated as a function of the reaction time. The results show that vertically aligned nanotubes of ≈700 nm in length, with highly ordered structures of ≈40 nm spacing and ≈15 nm wall thickness may be grown independent of reaction time. The geometrical properties of nanotubes increase with reaction time (mean pore size, pore size distribution [PSD], and porosity ≈90 nm, ≈40–127 nm and 45%, respectively for 30 minutes; ≈107 nm, ≈63–140 nm and 56% for one hour; ≈108 nm, ≈58–150 nm and 60% for three hours). It is found that the fluorinated chemistry of the nanotubes of F-TiO2, TiOF2, and F-Ti-O with F ion incorporation of ≈5 at.%, and their amorphous structure is the same regardless of the reaction time, while the average roughness (Sa) gradually decreases and the developed surface area (Sdr) slightly increases with reaction time. The results of studies on animals show that, despite their low roughness values, after six weeks the fluorinated TiO2 nanotube implants in rabbit femurs demonstrate significantly increased osseointegration strengths (41 vs 29 Ncm; P = 0.008) and new bone formation (57.5% vs 65.5%; P = 0.008) (n = 8), and reveal more frequently direct bone/cell contact at the bone–implant interface by high-resolution scanning electron microscope observations as compared with the blasted, moderately rough implants that have hitherto been widely used for clinically favorable performance. The results of the animal studies constitute significant evidence that the presence of the nanotubes and the resulting fluorinated surface chemistry determine the nature of the bone responses to the implants. The present in vivo results point to potential applications of the TiO2 nanotubes in the field of bone implants and bone tissue engineering.Keywords: electrochemical fabrication, fluorinated TiO2 nanotubes, surface properties, osseointegrated titanium implant, in vivo bone response
format article
author Young-Taeg Sul
author_facet Young-Taeg Sul
author_sort Young-Taeg Sul
title Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
title_short Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
title_full Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
title_fullStr Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
title_full_unstemmed Electrochemical growth behavior, surface properties, and enhanced in vivo bone response of TiO2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
title_sort electrochemical growth behavior, surface properties, and enhanced in vivo bone response of tio2 nanotubes on microstructured surfaces of blasted, screw-shaped titanium implants
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/ed87daeabcfa465c93fe893523a1e887
work_keys_str_mv AT youngtaegsul electrochemicalgrowthbehaviorsurfacepropertiesandenhancedinvivoboneresponseoftio2nanotubesonmicrostructuredsurfacesofblastedscrewshapedtitaniumimplants
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