DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES

The article presents novel data concerning measurements of cytokine levels (IFNγ, IL-4, IL-6, IL-10, TNFβ, MCP-1), and cell adhesion molecules (sE-Selectin, sICAM-1) in blood plasma, llike as parameters of their diagnostic efficiency in the patients with thyroid autoimmune diseases (TAD), thyroid ad...

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Autor principal:	S. P. Kazakov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	cytokines adhesion factors autoimmune disorders adenoma cancer thyroid Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/ed88cd5fabd549ff9bfe52f7b8fcc010
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spelling	oai:doaj.org-article:ed88cd5fabd549ff9bfe52f7b8fcc0102021-11-18T08:03:41ZDIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES1563-06252313-741X10.15789/1563-0625-2010-6-559-564https://doaj.org/article/ed88cd5fabd549ff9bfe52f7b8fcc0102014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/474https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe article presents novel data concerning measurements of cytokine levels (IFNγ, IL-4, IL-6, IL-10, TNFβ, MCP-1), and cell adhesion molecules (sE-Selectin, sICAM-1) in blood plasma, llike as parameters of their diagnostic efficiency in the patients with thyroid autoimmune diseases (TAD), thyroid adenoma and cancer. The cytokines were analyzed by flow cytometris technique. We have shown that IL-4, IL-6, TNFβ, MCP-1 cytokines play an important role in pathogenesis of TAD, especially IL- 6, MCP-1. In cases of thyroid adenoma, a sufficient role belongs to IL-6, IL-10, TNFβ, MCP-1, sICAM-1, with IL-6 и sICAM-1 showing most significant changes. In thyroid cancer, IL-6, IL-10, MCP-1, sE-seleсtin are informative, with sE-seleсtin being the most reliable marker. In differential diagnostic between thyroid cancer and autoimmune diseases, one should employ such cytokines, as IL-10, MCP-1, sE-seleсtin, the latter being most significant. Differential diagnostics between thyroid adenoma and autoimmune diseases suggests determination of IL-6, IL-10 and sICAM-1 levels, preferring IL-6 and sICAM-1for their better diagnostic efficiency. Threshold levels of IL-6, sE-seleсtin may discriminate between thyroid cancer and adenoma, but these differences are of poor diagnostic efficiency.S. P. KazakovSPb RAACIarticlecytokinesadhesion factorsautoimmune disordersadenomacancerthyroidImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 12, Iss 6, Pp 559-564 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines adhesion factors autoimmune disorders adenoma cancer thyroid Immunologic diseases. Allergy RC581-607
spellingShingle	cytokines adhesion factors autoimmune disorders adenoma cancer thyroid Immunologic diseases. Allergy RC581-607 S. P. Kazakov DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
description	The article presents novel data concerning measurements of cytokine levels (IFNγ, IL-4, IL-6, IL-10, TNFβ, MCP-1), and cell adhesion molecules (sE-Selectin, sICAM-1) in blood plasma, llike as parameters of their diagnostic efficiency in the patients with thyroid autoimmune diseases (TAD), thyroid adenoma and cancer. The cytokines were analyzed by flow cytometris technique. We have shown that IL-4, IL-6, TNFβ, MCP-1 cytokines play an important role in pathogenesis of TAD, especially IL- 6, MCP-1. In cases of thyroid adenoma, a sufficient role belongs to IL-6, IL-10, TNFβ, MCP-1, sICAM-1, with IL-6 и sICAM-1 showing most significant changes. In thyroid cancer, IL-6, IL-10, MCP-1, sE-seleсtin are informative, with sE-seleсtin being the most reliable marker. In differential diagnostic between thyroid cancer and autoimmune diseases, one should employ such cytokines, as IL-10, MCP-1, sE-seleсtin, the latter being most significant. Differential diagnostics between thyroid adenoma and autoimmune diseases suggests determination of IL-6, IL-10 and sICAM-1 levels, preferring IL-6 and sICAM-1for their better diagnostic efficiency. Threshold levels of IL-6, sE-seleсtin may discriminate between thyroid cancer and adenoma, but these differences are of poor diagnostic efficiency.
format	article
author	S. P. Kazakov
author_facet	S. P. Kazakov
author_sort	S. P. Kazakov
title	DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
title_short	DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
title_full	DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
title_fullStr	DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
title_full_unstemmed	DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES
title_sort	differential levels of cytokines and intercellular adhesion molecules and their diagnostic efficiency in autoimmune and oncological thyroid diseases
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/ed88cd5fabd549ff9bfe52f7b8fcc010
work_keys_str_mv	AT spkazakov differentiallevelsofcytokinesandintercellularadhesionmoleculesandtheirdiagnosticefficiencyinautoimmuneandoncologicalthyroiddiseases
_version_	1718422515895762944

DIFFERENTIAL LEVELS OF CYTOKINES AND INTERCELLULAR ADHESION MOLECULES AND THEIR DIAGNOSTIC EFFICIENCY IN AUTOIMMUNE AND ONCOLOGICAL THYROID DISEASES

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