Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

Abstract Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather than oxidative phosphorylation even in the presence of oxygen. However, recent studies have shown that certain cancer cells display in...

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Auteurs principaux:	Sajad Dar, Jasdeep Chhina, Ismail Mert, Dhananjay Chitale, Thomas Buekers, Hareena Kaur, Shailendra Giri, Adnan Munkarah, Ramandeep Rattan
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/ed8a80676c7b444b9a13654d9dc738bc
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spelling	oai:doaj.org-article:ed8a80676c7b444b9a13654d9dc738bc2021-12-02T15:06:18ZBioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells10.1038/s41598-017-09206-02045-2322https://doaj.org/article/ed8a80676c7b444b9a13654d9dc738bc2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09206-0https://doaj.org/toc/2045-2322Abstract Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather than oxidative phosphorylation even in the presence of oxygen. However, recent studies have shown that certain cancer cells display increased oxidative phosphorylation or high metabolically active phenotype. Cellular bioenergetic profiling of 13 established and 12 patient derived ovarian cancer cell lines revealed significant bioenergetics diversity. The bioenergetics phenotype of ovarian cancer cell lines correlated with functional phenotypes of doubling time and oxidative stress. Interestingly, chemosensitive cancer cell lines (A2780 and PEO1) displayed a glycolytic phenotype while their chemoresistant counterparts (C200 and PEO4) exhibited a high metabolically active phenotype with the ability to switch between oxidative phosphorylation or glycolysis. The chemosensitive cancer cells could not survive glucose deprivation, while the chemoresistant cells displayed adaptability. In the patient derived ovarian cancer cells, a similar correlation was observed between a high metabolically active phenotype and chemoresistance. Thus, ovarian cancer cells seem to display heterogeneity in using glycolysis or oxidative phosphorylation as an energy source. The flexibility in using different energy pathways may indicate a survival adaptation to achieve a higher ‘cellular fitness’ that may be also associated with chemoresistance.Sajad DarJasdeep ChhinaIsmail MertDhananjay ChitaleThomas BuekersHareena KaurShailendra GiriAdnan MunkarahRamandeep RattanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sajad Dar Jasdeep Chhina Ismail Mert Dhananjay Chitale Thomas Buekers Hareena Kaur Shailendra Giri Adnan Munkarah Ramandeep Rattan Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
description	Abstract Earlier investigations have revealed that tumor cells undergo metabolic reprogramming and mainly derive their cellular energy from aerobic glycolysis rather than oxidative phosphorylation even in the presence of oxygen. However, recent studies have shown that certain cancer cells display increased oxidative phosphorylation or high metabolically active phenotype. Cellular bioenergetic profiling of 13 established and 12 patient derived ovarian cancer cell lines revealed significant bioenergetics diversity. The bioenergetics phenotype of ovarian cancer cell lines correlated with functional phenotypes of doubling time and oxidative stress. Interestingly, chemosensitive cancer cell lines (A2780 and PEO1) displayed a glycolytic phenotype while their chemoresistant counterparts (C200 and PEO4) exhibited a high metabolically active phenotype with the ability to switch between oxidative phosphorylation or glycolysis. The chemosensitive cancer cells could not survive glucose deprivation, while the chemoresistant cells displayed adaptability. In the patient derived ovarian cancer cells, a similar correlation was observed between a high metabolically active phenotype and chemoresistance. Thus, ovarian cancer cells seem to display heterogeneity in using glycolysis or oxidative phosphorylation as an energy source. The flexibility in using different energy pathways may indicate a survival adaptation to achieve a higher ‘cellular fitness’ that may be also associated with chemoresistance.
format	article
author	Sajad Dar Jasdeep Chhina Ismail Mert Dhananjay Chitale Thomas Buekers Hareena Kaur Shailendra Giri Adnan Munkarah Ramandeep Rattan
author_facet	Sajad Dar Jasdeep Chhina Ismail Mert Dhananjay Chitale Thomas Buekers Hareena Kaur Shailendra Giri Adnan Munkarah Ramandeep Rattan
author_sort	Sajad Dar
title	Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
title_short	Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
title_full	Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
title_fullStr	Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
title_full_unstemmed	Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells
title_sort	bioenergetic adaptations in chemoresistant ovarian cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/ed8a80676c7b444b9a13654d9dc738bc
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Bioenergetic Adaptations in Chemoresistant Ovarian Cancer Cells

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