IL-7 signalling represses Bcl-6 and the TFH gene program

It remains incompletely understood how cytokines shape TH1 cell differentiation to central memory T (TCM) and follicular T helper (TFH) cells. Here the authors show that TH1 cells can co-initiate the expression of both TFH and TCM gene programs and that IL-7 signalling represses TFH-associated but n...

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Autores principales:	Paul W. McDonald, Kaitlin A. Read, Chandra E. Baker, Ashlyn E. Anderson, Michael D. Powell, André Ballesteros-Tato, Kenneth J. Oestreich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed8ba91356794cf9a2f6d0b4dfd365cb
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spelling	oai:doaj.org-article:ed8ba91356794cf9a2f6d0b4dfd365cb2021-12-02T17:33:19ZIL-7 signalling represses Bcl-6 and the TFH gene program10.1038/ncomms102852041-1723https://doaj.org/article/ed8ba91356794cf9a2f6d0b4dfd365cb2016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10285https://doaj.org/toc/2041-1723It remains incompletely understood how cytokines shape TH1 cell differentiation to central memory T (TCM) and follicular T helper (TFH) cells. Here the authors show that TH1 cells can co-initiate the expression of both TFH and TCM gene programs and that IL-7 signalling represses TFH-associated but not TCM-associated genes.Paul W. McDonaldKaitlin A. ReadChandra E. BakerAshlyn E. AndersonMichael D. PowellAndré Ballesteros-TatoKenneth J. OestreichNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul W. McDonald Kaitlin A. Read Chandra E. Baker Ashlyn E. Anderson Michael D. Powell André Ballesteros-Tato Kenneth J. Oestreich IL-7 signalling represses Bcl-6 and the TFH gene program
description	It remains incompletely understood how cytokines shape TH1 cell differentiation to central memory T (TCM) and follicular T helper (TFH) cells. Here the authors show that TH1 cells can co-initiate the expression of both TFH and TCM gene programs and that IL-7 signalling represses TFH-associated but not TCM-associated genes.
format	article
author	Paul W. McDonald Kaitlin A. Read Chandra E. Baker Ashlyn E. Anderson Michael D. Powell André Ballesteros-Tato Kenneth J. Oestreich
author_facet	Paul W. McDonald Kaitlin A. Read Chandra E. Baker Ashlyn E. Anderson Michael D. Powell André Ballesteros-Tato Kenneth J. Oestreich
author_sort	Paul W. McDonald
title	IL-7 signalling represses Bcl-6 and the TFH gene program
title_short	IL-7 signalling represses Bcl-6 and the TFH gene program
title_full	IL-7 signalling represses Bcl-6 and the TFH gene program
title_fullStr	IL-7 signalling represses Bcl-6 and the TFH gene program
title_full_unstemmed	IL-7 signalling represses Bcl-6 and the TFH gene program
title_sort	il-7 signalling represses bcl-6 and the tfh gene program
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/ed8ba91356794cf9a2f6d0b4dfd365cb
work_keys_str_mv	AT paulwmcdonald il7signallingrepressesbcl6andthetfhgeneprogram AT kaitlinaread il7signallingrepressesbcl6andthetfhgeneprogram AT chandraebaker il7signallingrepressesbcl6andthetfhgeneprogram AT ashlyneanderson il7signallingrepressesbcl6andthetfhgeneprogram AT michaeldpowell il7signallingrepressesbcl6andthetfhgeneprogram AT andreballesterostato il7signallingrepressesbcl6andthetfhgeneprogram AT kennethjoestreich il7signallingrepressesbcl6andthetfhgeneprogram
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IL-7 signalling represses Bcl-6 and the TFH gene program

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