Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study

Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of...

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Autores principales:	Yao Cheng, Haoyue Teng, Yue Xiao, Mengxin Yao, Jieyun Yin, Guoqing Sun
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 pregnancy infant neurobehavioral development ASQ-3 SARS-CoV-2 Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/ed8c32ee68fd43df90f89240b44f2bcb
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spelling	oai:doaj.org-article:ed8c32ee68fd43df90f89240b44f2bcb2021-12-02T11:46:28ZImpact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study2296-236010.3389/fped.2021.762684https://doaj.org/article/ed8c32ee68fd43df90f89240b44f2bcb2021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fped.2021.762684/fullhttps://doaj.org/toc/2296-2360Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Wuhan Maternal and Child Health Hospital, China. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.Yao ChengHaoyue TengYue XiaoMengxin YaoJieyun YinGuoqing SunFrontiers Media S.A.articleCOVID-19pregnancyinfant neurobehavioral developmentASQ-3SARS-CoV-2PediatricsRJ1-570ENFrontiers in Pediatrics, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 pregnancy infant neurobehavioral development ASQ-3 SARS-CoV-2 Pediatrics RJ1-570
spellingShingle	COVID-19 pregnancy infant neurobehavioral development ASQ-3 SARS-CoV-2 Pediatrics RJ1-570 Yao Cheng Haoyue Teng Yue Xiao Mengxin Yao Jieyun Yin Guoqing Sun Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
description	Background: Previous studies on the pneumonia outbreak caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have focused on the general population and pregnant women, while little is known about the effects of SARS-CoV-2 on retardation during and after pregnancy. The purpose of this study was to evaluate the potential influence of SARS-CoV-2 on infant neurobehavioral development.Methods: A case-control study was conducted in Wuhan Maternal and Child Health Hospital, China. Nine pregnant women with SARS-CoV-2 infection and 9 controls matched by maternal age, parity, and status of chronic disease were included. Infantile neurobehavioral development was assessed through the Ages and Stages Questionnaires Edition 3 (ASQ-3).Results: The majority of pregnant women with SARS-CoV-2 experienced cesarean section (7 of 9), which was higher than the control group (5 of 9). The throat swabs of all newborn were negative. We found that compared with the control group, neonates of mothers with SARS-CoV-2 infection during pregnancy had lower scores in communication, gross movement, fine movement, problem solving, and personal-social domains; but only fine movement domain yielded statistical significance (P = 0.031).Conclusion: Infection with SARS-CoV-2 during pregnancy may have a certain impact on infant neurobehavioral development. Further studies with larger sample size are warranted for validation.
format	article
author	Yao Cheng Haoyue Teng Yue Xiao Mengxin Yao Jieyun Yin Guoqing Sun
author_facet	Yao Cheng Haoyue Teng Yue Xiao Mengxin Yao Jieyun Yin Guoqing Sun
author_sort	Yao Cheng
title	Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
title_short	Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
title_full	Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
title_fullStr	Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
title_full_unstemmed	Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study
title_sort	impact of sars-cov-2 infection during pregnancy on infant neurobehavioral development: a case-control study
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/ed8c32ee68fd43df90f89240b44f2bcb
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Impact of SARS-CoV-2 Infection During Pregnancy on Infant Neurobehavioral Development: A Case-Control Study

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