GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.

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Autores principales:	Daniel M. Kremer, Barbara S. Nelson, Lin Lin, Emily L. Yarosz, Christopher J. Halbrook, Samuel A. Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W. Hou, Eileen S. Carpenter, Anthony C. Andren, Zeribe C. Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E. Mbah, Mengrou Shan, Nupur K. Das, Brian Magnuson, Andrew C. Little, Milan R. Savani, Johanna Ramos, Tina Gao, Stephen A. Sastra, Carmine F. Palermo, Michael A. Badgley, Li Zhang, John M. Asara, Samuel K. McBrayer, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Kenneth P. Olive, Costas A. Lyssiotis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
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spelling	oai:doaj.org-article:ed8c3b2903a54147ade49ed6c779e8e52021-12-02T16:27:51ZGOT1 inhibition promotes pancreatic cancer cell death by ferroptosis10.1038/s41467-021-24859-22041-1723https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e52021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24859-2https://doaj.org/toc/2041-1723The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.Daniel M. KremerBarbara S. NelsonLin LinEmily L. YaroszChristopher J. HalbrookSamuel A. KerkPeter SajjakulnukitAmy MyersGalloway ThurstonSean W. HouEileen S. CarpenterAnthony C. AndrenZeribe C. NwosuNicholas CusmanoStephanie WisnerNneka E. MbahMengrou ShanNupur K. DasBrian MagnusonAndrew C. LittleMilan R. SavaniJohanna RamosTina GaoStephen A. SastraCarmine F. PalermoMichael A. BadgleyLi ZhangJohn M. AsaraSamuel K. McBrayerMarina Pasca di MaglianoHoward C. CrawfordYatrik M. ShahKenneth P. OliveCostas A. LyssiotisNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
description	The aspartate aminotransaminase GOT1 is important for maintaining redox balance. Here, the authors show that inhibition of GOT1 in pancreatic cancer cells leads to cell death via ferroptosis.
format	article
author	Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis
author_facet	Daniel M. Kremer Barbara S. Nelson Lin Lin Emily L. Yarosz Christopher J. Halbrook Samuel A. Kerk Peter Sajjakulnukit Amy Myers Galloway Thurston Sean W. Hou Eileen S. Carpenter Anthony C. Andren Zeribe C. Nwosu Nicholas Cusmano Stephanie Wisner Nneka E. Mbah Mengrou Shan Nupur K. Das Brian Magnuson Andrew C. Little Milan R. Savani Johanna Ramos Tina Gao Stephen A. Sastra Carmine F. Palermo Michael A. Badgley Li Zhang John M. Asara Samuel K. McBrayer Marina Pasca di Magliano Howard C. Crawford Yatrik M. Shah Kenneth P. Olive Costas A. Lyssiotis
author_sort	Daniel M. Kremer
title	GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
title_short	GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
title_full	GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
title_fullStr	GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
title_full_unstemmed	GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis
title_sort	got1 inhibition promotes pancreatic cancer cell death by ferroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed8c3b2903a54147ade49ed6c779e8e5
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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

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