Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis

The aim of this study is to evaluate prognostic and therapeutic implications of microvessel density (MVD) in the recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) in prostate cancer (PCa). As of April 2019, EMBASE, PubMed, Cochrane Library, Science Direct/Els...

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Autores principales:	Feng Guangui, Wang Kai, Jiang Zhao
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2021
Materias:	microvessel density angiogenesis pca prognosis meta-analysis Medicine R
Acceso en línea:	https://doaj.org/article/ed8ec58cdafd4259953d74692f979afc
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spelling	oai:doaj.org-article:ed8ec58cdafd4259953d74692f979afc2021-12-05T14:10:53ZMicrovessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis2391-546310.1515/med-2020-0235https://doaj.org/article/ed8ec58cdafd4259953d74692f979afc2021-06-01T00:00:00Zhttps://doi.org/10.1515/med-2020-0235https://doaj.org/toc/2391-5463The aim of this study is to evaluate prognostic and therapeutic implications of microvessel density (MVD) in the recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) in prostate cancer (PCa). As of April 2019, EMBASE, PubMed, Cochrane Library, Science Direct/Elsevier, MEDLINE, and CNKI are used for systematic literature retrieval to investigate the correlation between MVD and PCa. Meta-analysis was performed using Review Manager and Stata software. Combined hazard ratio (HR) was identified with 95% confidence intervals (95% CI) in a random or fixed effects model. Thirteen studies were identified in this article. Of which, 8 studies analyzed for the recurrence-free survival (2,399 patients) demonstrated that MVD significantly elevated in the poor recurrence-free survival (HR 2.57, 95% CI 2.21–2.97). Other 2 eligible studies (330 patients) with 3 data sets for the MVD-OS analysis and the pooled HR (HR 1.70, 95% CI 1.27–2.28) suggested a weak risk of overall death rate in patients with high-MVD levels. The last 3 studies for disease-specific survival (220 patients) suggested that the association with high MVD and disease-specific survival may not have statistically significance (HR 1.32, 95% CI 0.49–3.56). This study suggests that high intratumoral MVD appears a significant progenitor for poor recurrence-free survival of PCa.Feng GuanguiWang KaiJiang ZhaoDe Gruyterarticlemicrovessel densityangiogenesispcaprognosismeta-analysisMedicineRENOpen Medicine, Vol 16, Iss 1, Pp 882-891 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	microvessel density angiogenesis pca prognosis meta-analysis Medicine R
spellingShingle	microvessel density angiogenesis pca prognosis meta-analysis Medicine R Feng Guangui Wang Kai Jiang Zhao Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
description	The aim of this study is to evaluate prognostic and therapeutic implications of microvessel density (MVD) in the recurrence-free survival (RFS), disease-specific survival (DSS), and overall survival (OS) in prostate cancer (PCa). As of April 2019, EMBASE, PubMed, Cochrane Library, Science Direct/Elsevier, MEDLINE, and CNKI are used for systematic literature retrieval to investigate the correlation between MVD and PCa. Meta-analysis was performed using Review Manager and Stata software. Combined hazard ratio (HR) was identified with 95% confidence intervals (95% CI) in a random or fixed effects model. Thirteen studies were identified in this article. Of which, 8 studies analyzed for the recurrence-free survival (2,399 patients) demonstrated that MVD significantly elevated in the poor recurrence-free survival (HR 2.57, 95% CI 2.21–2.97). Other 2 eligible studies (330 patients) with 3 data sets for the MVD-OS analysis and the pooled HR (HR 1.70, 95% CI 1.27–2.28) suggested a weak risk of overall death rate in patients with high-MVD levels. The last 3 studies for disease-specific survival (220 patients) suggested that the association with high MVD and disease-specific survival may not have statistically significance (HR 1.32, 95% CI 0.49–3.56). This study suggests that high intratumoral MVD appears a significant progenitor for poor recurrence-free survival of PCa.
format	article
author	Feng Guangui Wang Kai Jiang Zhao
author_facet	Feng Guangui Wang Kai Jiang Zhao
author_sort	Feng Guangui
title	Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
title_short	Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
title_full	Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
title_fullStr	Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
title_full_unstemmed	Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis
title_sort	microvessel density as a prognostic indicator of prostate cancer: a systematic review and meta-analysis
publisher	De Gruyter
publishDate	2021
url	https://doaj.org/article/ed8ec58cdafd4259953d74692f979afc
work_keys_str_mv	AT fengguangui microvesseldensityasaprognosticindicatorofprostatecancerasystematicreviewandmetaanalysis AT wangkai microvesseldensityasaprognosticindicatorofprostatecancerasystematicreviewandmetaanalysis AT jiangzhao microvesseldensityasaprognosticindicatorofprostatecancerasystematicreviewandmetaanalysis
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Microvessel density as a prognostic indicator of prostate cancer: A systematic review and meta-analysis

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