Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study

Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of...

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Autores principales:	Hye Yeon Koo, Kyungdo Han, Dong Wook Shin, Jung Eun Yoo, Mi Hee Cho, Keun Hye Jeon, Dahye Kim, Sangduk Hong, Jae Kwan Jun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	head and neck neoplasms alcohol drinking drinking behavior risk factors cohort studies Medicine R
Acceso en línea:	https://doaj.org/article/ed9656ed55d543f7b941947d40d60ae2
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spelling	oai:doaj.org-article:ed9656ed55d543f7b941947d40d60ae22021-11-11T16:21:17ZAlcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study10.3390/ijerph1821112041660-46011661-7827https://doaj.org/article/ed9656ed55d543f7b941947d40d60ae22021-10-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11204https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency (<i>p</i>-trend < 0.01; adjusted hazard ratio [aHR] 1.55, 95% confidence interval [CI] 1.45–1.67 in subjects who drank 7 days/week). HNC risk also increased according to daily amount of alcohol consumption (<i>p</i>-trend < 0.01), but plateaued from 5–7 units/occasion (aHR 1.25, 95% CI 1.19–1.31) to >14 units/occasion (aHR 1.26, 95% CI 1.13–1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption.Hye Yeon KooKyungdo HanDong Wook ShinJung Eun YooMi Hee ChoKeun Hye JeonDahye KimSangduk HongJae Kwan JunMDPI AGarticlehead and neck neoplasmsalcohol drinkingdrinking behaviorrisk factorscohort studiesMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11204, p 11204 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	head and neck neoplasms alcohol drinking drinking behavior risk factors cohort studies Medicine R
spellingShingle	head and neck neoplasms alcohol drinking drinking behavior risk factors cohort studies Medicine R Hye Yeon Koo Kyungdo Han Dong Wook Shin Jung Eun Yoo Mi Hee Cho Keun Hye Jeon Dahye Kim Sangduk Hong Jae Kwan Jun Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
description	Alcohol consumption is a major risk factor for head and neck cancer (HNC), yet little data exist examining drinking patterns and HNC risk. In this population-based, retrospective cohort study, 11,737,467 subjects were recruited from the Korean National Health Insurance Service database. The risks of overall HNC and HNC subtypes according to average alcohol consumption, drinking frequency, and daily amount were examined using Cox proportional hazard models. Over the median follow-up of 6.4 years, 15,832 HNC cases were identified. HNC risk linearly increased with drinking frequency (<i>p</i>-trend < 0.01; adjusted hazard ratio [aHR] 1.55, 95% confidence interval [CI] 1.45–1.67 in subjects who drank 7 days/week). HNC risk also increased according to daily amount of alcohol consumption (<i>p</i>-trend < 0.01), but plateaued from 5–7 units/occasion (aHR 1.25, 95% CI 1.19–1.31) to >14 units/occasion (aHR 1.26, 95% CI 1.13–1.40). When stratified by average alcohol consumption, drinking frequency, but not daily amount, showed a linear relationship with HNC risk in moderate and heavy drinkers. When comparing the HNC subtypes, similar tendencies were observed in cancers of the oral cavity, pharynx, and larynx, but not in the salivary gland. In conclusion, drinking frequency is a stronger risk factor for HNC, especially for cancer of the oral cavity, pharynx, and larynx, than the daily amount of alcohol consumption.
format	article
author	Hye Yeon Koo Kyungdo Han Dong Wook Shin Jung Eun Yoo Mi Hee Cho Keun Hye Jeon Dahye Kim Sangduk Hong Jae Kwan Jun
author_facet	Hye Yeon Koo Kyungdo Han Dong Wook Shin Jung Eun Yoo Mi Hee Cho Keun Hye Jeon Dahye Kim Sangduk Hong Jae Kwan Jun
author_sort	Hye Yeon Koo
title	Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
title_short	Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
title_full	Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
title_fullStr	Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
title_full_unstemmed	Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study
title_sort	alcohol drinking pattern and risk of head and neck cancer: a nationwide cohort study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/ed9656ed55d543f7b941947d40d60ae2
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Alcohol Drinking Pattern and Risk of Head and Neck Cancer: A Nationwide Cohort Study

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