Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice
Abstract Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype...
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Nature Portfolio
2017
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oai:doaj.org-article:ed979dea50a644cfadbe6ed3499fab452021-12-02T15:05:34ZNovel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice10.1038/s41598-017-04946-52045-2322https://doaj.org/article/ed979dea50a644cfadbe6ed3499fab452017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04946-5https://doaj.org/toc/2045-2322Abstract Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women.Daimei SasayamaNobuhiro SugiyamaShigeru YonekuboAkiko PawlakHiroyasu MurasawaMie NakamuraMorimichi HayashiTakashi OgawaMakoto MoroShinsuke WashizukaNaoji AmanoKazuhiro HongoHideki OhnotaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017) |
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Medicine R Science Q Daimei Sasayama Nobuhiro Sugiyama Shigeru Yonekubo Akiko Pawlak Hiroyasu Murasawa Mie Nakamura Morimichi Hayashi Takashi Ogawa Makoto Moro Shinsuke Washizuka Naoji Amano Kazuhiro Hongo Hideki Ohnota Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| description |
Abstract Hormonal changes due to menopause can cause various health problems including weight gain and depressive symptoms. Multiple lines of evidence indicate that oestrogen receptors (ERs) play a major role in postmenopausal obesity and depression. However, little is known regarding the ER subtype-specific effects on obesity and depressive symptoms. To delineate potential effects of ERβ activation in postmenopausal women, we investigated the effects of a novel oestrogen receptor β-selective ligand (C-1) in ovariectomized mice. Uterine weight, depressive behaviour, and weight gain were examined in sham-operated control mice and ovariectomized mice administered placebo, C-1, or 17β-oestradiol (E2). Administration of C-1 or E2 reduced body weight gain and depressive-like behaviour in ovariectomized mice, as assessed by the forced swim test. In addition, administration of E2 to ovariectomized mice increased uterine weight, but administration of C-1 did not result in a significant increase in uterine weight. These results suggest that the selective activation of ERβ in ovariectomized mice may have protective effects against obesity and depressive-like behaviour without causing an increase in uterine weight. The present findings raise the possibility of the application of ERβ-ligands such as C-1 as a novel treatment for obesity and depression in postmenopausal women. |
| format |
article |
| author |
Daimei Sasayama Nobuhiro Sugiyama Shigeru Yonekubo Akiko Pawlak Hiroyasu Murasawa Mie Nakamura Morimichi Hayashi Takashi Ogawa Makoto Moro Shinsuke Washizuka Naoji Amano Kazuhiro Hongo Hideki Ohnota |
| author_facet |
Daimei Sasayama Nobuhiro Sugiyama Shigeru Yonekubo Akiko Pawlak Hiroyasu Murasawa Mie Nakamura Morimichi Hayashi Takashi Ogawa Makoto Moro Shinsuke Washizuka Naoji Amano Kazuhiro Hongo Hideki Ohnota |
| author_sort |
Daimei Sasayama |
| title |
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| title_short |
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| title_full |
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| title_fullStr |
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| title_full_unstemmed |
Novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| title_sort |
novel oestrogen receptor β-selective ligand reduces obesity and depressive-like behaviour in ovariectomized mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/ed979dea50a644cfadbe6ed3499fab45 |
| work_keys_str_mv |
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