Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer

Gupta et al. demonstrate that targeting isoform-specific TGFβ leads to an increase in the anti-tumor response when compared to pan-TGFβ inhibition, due to enhanced CD8 T cell function. The authors also report that combining TGFβ inhibition with immune checkpoint blockade results in improved tumor co...

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Autores principales:	Aditi Gupta, Sadna Budhu, Kelly Fitzgerald, Rachel Giese, Adam O. Michel, Aliya Holland, Luis Felipe Campesato, Jacques van Snick, Catherine Uyttenhove, Gerd Ritter, Jedd D. Wolchok, Taha Merghoub
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/ed988a10eff742c391e7da0374286113
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spelling	oai:doaj.org-article:ed988a10eff742c391e7da03742861132021-11-21T12:08:39ZIsoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer10.1038/s42003-021-02773-z2399-3642https://doaj.org/article/ed988a10eff742c391e7da03742861132021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02773-zhttps://doaj.org/toc/2399-3642Gupta et al. demonstrate that targeting isoform-specific TGFβ leads to an increase in the anti-tumor response when compared to pan-TGFβ inhibition, due to enhanced CD8 T cell function. The authors also report that combining TGFβ inhibition with immune checkpoint blockade results in improved tumor control.Aditi GuptaSadna BudhuKelly FitzgeraldRachel GieseAdam O. MichelAliya HollandLuis Felipe CampesatoJacques van SnickCatherine UyttenhoveGerd RitterJedd D. WolchokTaha MerghoubNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Aditi Gupta Sadna Budhu Kelly Fitzgerald Rachel Giese Adam O. Michel Aliya Holland Luis Felipe Campesato Jacques van Snick Catherine Uyttenhove Gerd Ritter Jedd D. Wolchok Taha Merghoub Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
description	Gupta et al. demonstrate that targeting isoform-specific TGFβ leads to an increase in the anti-tumor response when compared to pan-TGFβ inhibition, due to enhanced CD8 T cell function. The authors also report that combining TGFβ inhibition with immune checkpoint blockade results in improved tumor control.
format	article
author	Aditi Gupta Sadna Budhu Kelly Fitzgerald Rachel Giese Adam O. Michel Aliya Holland Luis Felipe Campesato Jacques van Snick Catherine Uyttenhove Gerd Ritter Jedd D. Wolchok Taha Merghoub
author_facet	Aditi Gupta Sadna Budhu Kelly Fitzgerald Rachel Giese Adam O. Michel Aliya Holland Luis Felipe Campesato Jacques van Snick Catherine Uyttenhove Gerd Ritter Jedd D. Wolchok Taha Merghoub
author_sort	Aditi Gupta
title	Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
title_short	Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
title_full	Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
title_fullStr	Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
title_full_unstemmed	Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer
title_sort	isoform specific anti-tgfβ therapy enhances antitumor efficacy in mouse models of cancer
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed988a10eff742c391e7da0374286113
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Isoform specific anti-TGFβ therapy enhances antitumor efficacy in mouse models of cancer

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