Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies
Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas.
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Nature Portfolio
2021
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oai:doaj.org-article:ed99a3d89b4343beb0ebcb86808840992021-12-02T15:23:10ZMapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies10.1038/s41467-021-24435-82041-1723https://doaj.org/article/ed99a3d89b4343beb0ebcb86808840992021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24435-8https://doaj.org/toc/2041-1723Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas.Allison J. GreaneyTyler N. StarrChristopher O. BarnesYiska WeisblumFabian SchmidtMarina CaskeyChristian GaeblerAlice ChoMarianna AgudeloShlomo FinkinZijun WangDaniel PostonFrauke MueckschTheodora HatziioannouPaul D. BieniaszDavide F. RobbianiMichel C. NussenzweigPamela J. BjorkmanJesse D. BloomNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Allison J. Greaney Tyler N. Starr Christopher O. Barnes Yiska Weisblum Fabian Schmidt Marina Caskey Christian Gaebler Alice Cho Marianna Agudelo Shlomo Finkin Zijun Wang Daniel Poston Frauke Muecksch Theodora Hatziioannou Paul D. Bieniasz Davide F. Robbiani Michel C. Nussenzweig Pamela J. Bjorkman Jesse D. Bloom Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| description |
Emerging SARS-CoV-2 mutants may escape neutralization by antibodies. Here, the authors use deep mutational scanning to identify mutations in the RBD that escape human monoclonal antibodies or convalescent plasmas. |
| format |
article |
| author |
Allison J. Greaney Tyler N. Starr Christopher O. Barnes Yiska Weisblum Fabian Schmidt Marina Caskey Christian Gaebler Alice Cho Marianna Agudelo Shlomo Finkin Zijun Wang Daniel Poston Frauke Muecksch Theodora Hatziioannou Paul D. Bieniasz Davide F. Robbiani Michel C. Nussenzweig Pamela J. Bjorkman Jesse D. Bloom |
| author_facet |
Allison J. Greaney Tyler N. Starr Christopher O. Barnes Yiska Weisblum Fabian Schmidt Marina Caskey Christian Gaebler Alice Cho Marianna Agudelo Shlomo Finkin Zijun Wang Daniel Poston Frauke Muecksch Theodora Hatziioannou Paul D. Bieniasz Davide F. Robbiani Michel C. Nussenzweig Pamela J. Bjorkman Jesse D. Bloom |
| author_sort |
Allison J. Greaney |
| title |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| title_short |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| title_full |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| title_fullStr |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| title_full_unstemmed |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies |
| title_sort |
mapping mutations to the sars-cov-2 rbd that escape binding by different classes of antibodies |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/ed99a3d89b4343beb0ebcb8680884099 |
| work_keys_str_mv |
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1718387300444930048 |