Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients

Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients

Abstract With polygenic risk score (PRS) for autoimmune type 1 diabetes (T1D), this study identified T1D cases with low T1D PRS and searched for susceptibility loci in these cases. Our hypothesis is that genetic effects (likely mediated by relatively rare genetic variants) of non-mainstream (or non-...

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Autores principales: Jingchun Qu, Hui-Qi Qu, Jonathan P. Bradfield, Joseph T. Glessner, Xiao Chang, Lifeng Tian, Michael March, John J. Connolly, Jeffrey D. Roizen, Patrick M. A. Sleiman, Hakon Hakonarson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/ed9a2299120543618940a4496e3810ca
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