Update on the effects of microgravity on the musculoskeletal system

Abstract With the reignited push for manned spaceflight and the development of companies focused on commercializing spaceflight, increased human ventures into space are inevitable. However, this venture would not be without risk. The lower gravitational force, known as microgravity, that would be ex...

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Autores principales:	Otto J. Juhl, Evan G. Buettmann, Michael A. Friedman, Rachel C. DeNapoli, Gabriel A. Hoppock, Henry J. Donahue
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biotechnology TP248.13-248.65 Physiology QP1-981
Acceso en línea:	https://doaj.org/article/ed9b1d0e085a49e593422d1e646e1e4e
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spelling	oai:doaj.org-article:ed9b1d0e085a49e593422d1e646e1e4e2021-12-02T16:18:01ZUpdate on the effects of microgravity on the musculoskeletal system10.1038/s41526-021-00158-42373-8065https://doaj.org/article/ed9b1d0e085a49e593422d1e646e1e4e2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41526-021-00158-4https://doaj.org/toc/2373-8065Abstract With the reignited push for manned spaceflight and the development of companies focused on commercializing spaceflight, increased human ventures into space are inevitable. However, this venture would not be without risk. The lower gravitational force, known as microgravity, that would be experienced during spaceflight significantly disrupts many physiological systems. One of the most notably affected systems is the musculoskeletal system, where exposure to microgravity causes both bone and skeletal muscle loss, both of which have significant clinical implications. In this review, we focus on recent advancements in our understanding of how exposure to microgravity affects the musculoskeletal system. We will focus on the catabolic effects microgravity exposure has on both bone and skeletal muscle cells, as well as their respective progenitor stem cells. Additionally, we report on the mechanisms that underlie bone and muscle tissue loss resulting from exposure to microgravity and then discuss current countermeasures being evaluated. We reveal the gaps in the current knowledge and expound upon how current research is filling these gaps while also identifying new avenues of study as we continue to pursue manned spaceflight.Otto J. JuhlEvan G. BuettmannMichael A. FriedmanRachel C. DeNapoliGabriel A. HoppockHenry J. DonahueNature PortfolioarticleBiotechnologyTP248.13-248.65PhysiologyQP1-981ENnpj Microgravity, Vol 7, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biotechnology TP248.13-248.65 Physiology QP1-981
spellingShingle	Biotechnology TP248.13-248.65 Physiology QP1-981 Otto J. Juhl Evan G. Buettmann Michael A. Friedman Rachel C. DeNapoli Gabriel A. Hoppock Henry J. Donahue Update on the effects of microgravity on the musculoskeletal system
description	Abstract With the reignited push for manned spaceflight and the development of companies focused on commercializing spaceflight, increased human ventures into space are inevitable. However, this venture would not be without risk. The lower gravitational force, known as microgravity, that would be experienced during spaceflight significantly disrupts many physiological systems. One of the most notably affected systems is the musculoskeletal system, where exposure to microgravity causes both bone and skeletal muscle loss, both of which have significant clinical implications. In this review, we focus on recent advancements in our understanding of how exposure to microgravity affects the musculoskeletal system. We will focus on the catabolic effects microgravity exposure has on both bone and skeletal muscle cells, as well as their respective progenitor stem cells. Additionally, we report on the mechanisms that underlie bone and muscle tissue loss resulting from exposure to microgravity and then discuss current countermeasures being evaluated. We reveal the gaps in the current knowledge and expound upon how current research is filling these gaps while also identifying new avenues of study as we continue to pursue manned spaceflight.
format	article
author	Otto J. Juhl Evan G. Buettmann Michael A. Friedman Rachel C. DeNapoli Gabriel A. Hoppock Henry J. Donahue
author_facet	Otto J. Juhl Evan G. Buettmann Michael A. Friedman Rachel C. DeNapoli Gabriel A. Hoppock Henry J. Donahue
author_sort	Otto J. Juhl
title	Update on the effects of microgravity on the musculoskeletal system
title_short	Update on the effects of microgravity on the musculoskeletal system
title_full	Update on the effects of microgravity on the musculoskeletal system
title_fullStr	Update on the effects of microgravity on the musculoskeletal system
title_full_unstemmed	Update on the effects of microgravity on the musculoskeletal system
title_sort	update on the effects of microgravity on the musculoskeletal system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed9b1d0e085a49e593422d1e646e1e4e
work_keys_str_mv	AT ottojjuhl updateontheeffectsofmicrogravityonthemusculoskeletalsystem AT evangbuettmann updateontheeffectsofmicrogravityonthemusculoskeletalsystem AT michaelafriedman updateontheeffectsofmicrogravityonthemusculoskeletalsystem AT rachelcdenapoli updateontheeffectsofmicrogravityonthemusculoskeletalsystem AT gabrielahoppock updateontheeffectsofmicrogravityonthemusculoskeletalsystem AT henryjdonahue updateontheeffectsofmicrogravityonthemusculoskeletalsystem
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Update on the effects of microgravity on the musculoskeletal system

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