Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study

Abstract Transcranial direct current stimulation (tDCS) have revealed the capability to augment various types of behavioural interventions. We aimed to augment the effects of mindfulness, suggested for reducing anxiety, with concurrent use of tDCS. We conducted a double-blind randomized study with 5...

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Autores principales:	Keiichiro Nishida, Yosuke Morishima, Roberto D. Pascual-Marqui, Shota Minami, Tomonari Yamane, Masahito Michikura, Hideki Ishikawa, Toshihiko Kinoshita
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed9b8e896d2348af8b385727537f7872
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spelling	oai:doaj.org-article:ed9b8e896d2348af8b385727537f78722021-11-28T12:19:08ZMindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study10.1038/s41598-021-02177-32045-2322https://doaj.org/article/ed9b8e896d2348af8b385727537f78722021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02177-3https://doaj.org/toc/2045-2322Abstract Transcranial direct current stimulation (tDCS) have revealed the capability to augment various types of behavioural interventions. We aimed to augment the effects of mindfulness, suggested for reducing anxiety, with concurrent use of tDCS. We conducted a double-blind randomized study with 58 healthy individuals. We introduced treadmill walking for focused meditation and active or sham tDCS on the left dorsolateral prefrontal cortex for 20 min. We evaluated outcomes using State-Trait Anxiety Inventory-State Anxiety (STAI) before the intervention as well as immediately, 60 min, and 1 week after the intervention, and current density from electroencephalograms (EEG) before and after the intervention. The linear mixed-effect models demonstrated that STAI-state anxiety showed a significant interaction effect between 1 week after the intervention and tDCS groups. As for alpha-band EEG activity, the current density in the rostral anterior cingulate cortex (rACC) was significantly reduced in the active compared with the sham stimulation group, and a significant correlation was seen between changes in STAI-trait anxiety and the current density of the rACC in the active stimulation group. Our study provided that despite this being a one-shot and short intervention, the reduction in anxiety lasts for one week, and EEG could potentially help predict its anxiolytic effect.Keiichiro NishidaYosuke MorishimaRoberto D. Pascual-MarquiShota MinamiTomonari YamaneMasahito MichikuraHideki IshikawaToshihiko KinoshitaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Keiichiro Nishida Yosuke Morishima Roberto D. Pascual-Marqui Shota Minami Tomonari Yamane Masahito Michikura Hideki Ishikawa Toshihiko Kinoshita Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
description	Abstract Transcranial direct current stimulation (tDCS) have revealed the capability to augment various types of behavioural interventions. We aimed to augment the effects of mindfulness, suggested for reducing anxiety, with concurrent use of tDCS. We conducted a double-blind randomized study with 58 healthy individuals. We introduced treadmill walking for focused meditation and active or sham tDCS on the left dorsolateral prefrontal cortex for 20 min. We evaluated outcomes using State-Trait Anxiety Inventory-State Anxiety (STAI) before the intervention as well as immediately, 60 min, and 1 week after the intervention, and current density from electroencephalograms (EEG) before and after the intervention. The linear mixed-effect models demonstrated that STAI-state anxiety showed a significant interaction effect between 1 week after the intervention and tDCS groups. As for alpha-band EEG activity, the current density in the rostral anterior cingulate cortex (rACC) was significantly reduced in the active compared with the sham stimulation group, and a significant correlation was seen between changes in STAI-trait anxiety and the current density of the rACC in the active stimulation group. Our study provided that despite this being a one-shot and short intervention, the reduction in anxiety lasts for one week, and EEG could potentially help predict its anxiolytic effect.
format	article
author	Keiichiro Nishida Yosuke Morishima Roberto D. Pascual-Marqui Shota Minami Tomonari Yamane Masahito Michikura Hideki Ishikawa Toshihiko Kinoshita
author_facet	Keiichiro Nishida Yosuke Morishima Roberto D. Pascual-Marqui Shota Minami Tomonari Yamane Masahito Michikura Hideki Ishikawa Toshihiko Kinoshita
author_sort	Keiichiro Nishida
title	Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
title_short	Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
title_full	Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
title_fullStr	Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
title_full_unstemmed	Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
title_sort	mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/ed9b8e896d2348af8b385727537f7872
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Mindfulness augmentation for anxiety through concurrent use of transcranial direct current stimulation: a randomized double-blind study

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