Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.

<h4>Background</h4>Lung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. However, whether CIP2A can be a new drug target for l...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liang Ma, Zhe-Sheng Wen, Zi Liu, Zheng Hu, Jun Ma, Xiao-Qin Chen, Yong-Qiang Liu, Jian-Xin Pu, Wei-Lie Xiao, Han-Dong Sun, Guang-Biao Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/ed9f011dd4fd4b52af44468804763a4e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:ed9f011dd4fd4b52af44468804763a4e
record_format	dspace
spelling	oai:doaj.org-article:ed9f011dd4fd4b52af44468804763a4e2021-11-18T06:52:49ZOverexpression and small molecule-triggered downregulation of CIP2A in lung cancer.1932-620310.1371/journal.pone.0020159https://doaj.org/article/ed9f011dd4fd4b52af44468804763a4e2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21655278/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Lung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. However, whether CIP2A can be a new drug target for lung cancer is largely unclear.<h4>Methodology/principal findings</h4>Normal and malignant lung tissues were derived from 60 lung cancer patients from southern China. RT-PCR, Western blotting and immunohistochemistry were used to evaluate the expression of CIP2A. We found that among the 60 patients, CIP2A was undetectable or very low in paratumor normal tissues, but was dramatically elevated in tumor samples in 38 (63.3%) patients. CIP2A overexpression was associated with cigarette smoking. Silencing CIP2A by siRNA inhibited the proliferation and clonogenic activity of lung cancer cells. Intriguingly, we found a natural compound, rabdocoetsin B which is extracted from a Traditional Chinese Medicinal herb Rabdosia coetsa, could induce down-regulation of CIP2A and inactivation of Akt pathway, and inhibit proliferation and induce apoptosis in a variety of lung cancer cells.<h4>Conclusions/significance</h4>Our findings strongly indicate that CIP2A could be an effective target for lung cancer drug development, and the therapeutic potentials of CIP2A-targeting agents warrant further investigation.Liang MaZhe-Sheng WenZi LiuZheng HuJun MaXiao-Qin ChenYong-Qiang LiuJian-Xin PuWei-Lie XiaoHan-Dong SunGuang-Biao ZhouGuang-Biao ZhouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e20159 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liang Ma Zhe-Sheng Wen Zi Liu Zheng Hu Jun Ma Xiao-Qin Chen Yong-Qiang Liu Jian-Xin Pu Wei-Lie Xiao Han-Dong Sun Guang-Biao Zhou Guang-Biao Zhou Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
description	<h4>Background</h4>Lung cancer is the leading cause of cancer deaths worldwide, with a five-year overall survival rate of only 15%. Cancerous inhibitor of PP2A (CIP2A) is a human oncoprotein inhibiting PP2A in many human malignancies. However, whether CIP2A can be a new drug target for lung cancer is largely unclear.<h4>Methodology/principal findings</h4>Normal and malignant lung tissues were derived from 60 lung cancer patients from southern China. RT-PCR, Western blotting and immunohistochemistry were used to evaluate the expression of CIP2A. We found that among the 60 patients, CIP2A was undetectable or very low in paratumor normal tissues, but was dramatically elevated in tumor samples in 38 (63.3%) patients. CIP2A overexpression was associated with cigarette smoking. Silencing CIP2A by siRNA inhibited the proliferation and clonogenic activity of lung cancer cells. Intriguingly, we found a natural compound, rabdocoetsin B which is extracted from a Traditional Chinese Medicinal herb Rabdosia coetsa, could induce down-regulation of CIP2A and inactivation of Akt pathway, and inhibit proliferation and induce apoptosis in a variety of lung cancer cells.<h4>Conclusions/significance</h4>Our findings strongly indicate that CIP2A could be an effective target for lung cancer drug development, and the therapeutic potentials of CIP2A-targeting agents warrant further investigation.
format	article
author	Liang Ma Zhe-Sheng Wen Zi Liu Zheng Hu Jun Ma Xiao-Qin Chen Yong-Qiang Liu Jian-Xin Pu Wei-Lie Xiao Han-Dong Sun Guang-Biao Zhou Guang-Biao Zhou
author_facet	Liang Ma Zhe-Sheng Wen Zi Liu Zheng Hu Jun Ma Xiao-Qin Chen Yong-Qiang Liu Jian-Xin Pu Wei-Lie Xiao Han-Dong Sun Guang-Biao Zhou Guang-Biao Zhou
author_sort	Liang Ma
title	Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
title_short	Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
title_full	Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
title_fullStr	Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
title_full_unstemmed	Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.
title_sort	overexpression and small molecule-triggered downregulation of cip2a in lung cancer.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/ed9f011dd4fd4b52af44468804763a4e
work_keys_str_mv	AT liangma overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT zheshengwen overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT ziliu overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT zhenghu overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT junma overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT xiaoqinchen overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT yongqiangliu overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT jianxinpu overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT weiliexiao overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT handongsun overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT guangbiaozhou overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer AT guangbiaozhou overexpressionandsmallmoleculetriggereddownregulationofcip2ainlungcancer
_version_	1718424264682504192

Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer.

Ejemplares similares