Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

Effects of heparin and enoxaparin on APP processing and Aβ production in primary cortical neurons from Tg2576 mice.

<h4>Background</h4>Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan...

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Main Authors: Hao Cui, Amos C Hung, David W Klaver, Toshiharu Suzuki, Craig Freeman, Christian Narkowicz, Glenn A Jacobson, David H Small
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2011
Subjects:
Medicine
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Science
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Online Access:https://doaj.org/article/eda00fd627b64d1b93cb1126837c49bd
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