A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions. Here, the authors report a method for the synthesis of NCAs under a...

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Autores principales: Zi-You Tian, Zhengchu Zhang, Shuo Wang, Hua Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/eda2208a5aff400f8ef4cbb4af82d0a5
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Sumario:Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions. Here, the authors report a method for the synthesis of NCAs under atmospheric conditions and room temperature, based on the use of epoxides as acid scavengers.