A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions. Here, the authors report a method for the synthesis of NCAs under a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zi-You Tian, Zhengchu Zhang, Shuo Wang, Hua Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/eda2208a5aff400f8ef4cbb4af82d0a5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:eda2208a5aff400f8ef4cbb4af82d0a5
record_format	dspace
spelling	oai:doaj.org-article:eda2208a5aff400f8ef4cbb4af82d0a52021-12-02T19:16:20ZA moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides10.1038/s41467-021-25689-y2041-1723https://doaj.org/article/eda2208a5aff400f8ef4cbb4af82d0a52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25689-yhttps://doaj.org/toc/2041-1723Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions. Here, the authors report a method for the synthesis of NCAs under atmospheric conditions and room temperature, based on the use of epoxides as acid scavengers.Zi-You TianZhengchu ZhangShuo WangHua LuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zi-You Tian Zhengchu Zhang Shuo Wang Hua Lu A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
description	Synthetic polypeptides are biomimetic materials that are commonly prepared by ring-opening polymerization of amino acid N-carboxyanhydrides (NCAs), but the methods for NCA synthesis usually require anhydrous and air-free conditions. Here, the authors report a method for the synthesis of NCAs under atmospheric conditions and room temperature, based on the use of epoxides as acid scavengers.
format	article
author	Zi-You Tian Zhengchu Zhang Shuo Wang Hua Lu
author_facet	Zi-You Tian Zhengchu Zhang Shuo Wang Hua Lu
author_sort	Zi-You Tian
title	A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
title_short	A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
title_full	A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
title_fullStr	A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
title_full_unstemmed	A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
title_sort	moisture-tolerant route to unprotected α/β-amino acid n-carboxyanhydrides and facile synthesis of hyperbranched polypeptides
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/eda2208a5aff400f8ef4cbb4af82d0a5
work_keys_str_mv	AT ziyoutian amoisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT zhengchuzhang amoisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT shuowang amoisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT hualu amoisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT ziyoutian moisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT zhengchuzhang moisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT shuowang moisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides AT hualu moisturetolerantroutetounprotectedabaminoacidncarboxyanhydridesandfacilesynthesisofhyperbranchedpolypeptides
_version_	1718377005001474048

A moisture-tolerant route to unprotected α/β-amino acid N-carboxyanhydrides and facile synthesis of hyperbranched polypeptides

Ejemplares similares