Effect of central lesions on a spinal circuit facilitating human wrist flexors

Abstract A putative spinal circuit with convergent inputs facilitating human wrist flexors has been recently described. This study investigated how central nervous system lesions may affect this pathway. We measured the flexor carpi radialis H-reflex conditioned with stimulation above motor threshol...

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Autores principales:	Stefane A. Aguiar, Supriyo Choudhury, Hrishikesh Kumar, Monica A. Perez, Stuart N. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Spinal Circuits Flexor Carpi Prolonged Facilitation Spinal Cord Injury Central Nervous System Lesions Medicine R Science Q
Acceso en línea:	https://doaj.org/article/eda2f84221274e3a94a9101631cd33c5
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spelling	oai:doaj.org-article:eda2f84221274e3a94a9101631cd33c52021-12-02T11:40:53ZEffect of central lesions on a spinal circuit facilitating human wrist flexors10.1038/s41598-018-33012-x2045-2322https://doaj.org/article/eda2f84221274e3a94a9101631cd33c52018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33012-xhttps://doaj.org/toc/2045-2322Abstract A putative spinal circuit with convergent inputs facilitating human wrist flexors has been recently described. This study investigated how central nervous system lesions may affect this pathway. We measured the flexor carpi radialis H-reflex conditioned with stimulation above motor threshold to the extensor carpi radialis at different intervals in fifteen patients with stroke and nine with spinal cord injury. Measurements after stroke revealed a prolonged facilitation of the H-reflex, which replaced the later suppression seen in healthy subjects at longer intervals (30–60 ms). Measurements in patients with incomplete spinal cord injury at cervical level revealed heterogeneous responses. Results from patients with stroke could represent either an excessive facilitation or a loss of inhibition, which may reflect the development of spasticity. Spinal cord injury results possibly reflect damage to the segmental interneuron pathways. We report a straightforward method to assess changes to spinal circuits controlling wrist flexors after central nervous system lesion.Stefane A. AguiarSupriyo ChoudhuryHrishikesh KumarMonica A. PerezStuart N. BakerNature PortfolioarticleSpinal CircuitsFlexor CarpiProlonged FacilitationSpinal Cord InjuryCentral Nervous System LesionsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Spinal Circuits Flexor Carpi Prolonged Facilitation Spinal Cord Injury Central Nervous System Lesions Medicine R Science Q
spellingShingle	Spinal Circuits Flexor Carpi Prolonged Facilitation Spinal Cord Injury Central Nervous System Lesions Medicine R Science Q Stefane A. Aguiar Supriyo Choudhury Hrishikesh Kumar Monica A. Perez Stuart N. Baker Effect of central lesions on a spinal circuit facilitating human wrist flexors
description	Abstract A putative spinal circuit with convergent inputs facilitating human wrist flexors has been recently described. This study investigated how central nervous system lesions may affect this pathway. We measured the flexor carpi radialis H-reflex conditioned with stimulation above motor threshold to the extensor carpi radialis at different intervals in fifteen patients with stroke and nine with spinal cord injury. Measurements after stroke revealed a prolonged facilitation of the H-reflex, which replaced the later suppression seen in healthy subjects at longer intervals (30–60 ms). Measurements in patients with incomplete spinal cord injury at cervical level revealed heterogeneous responses. Results from patients with stroke could represent either an excessive facilitation or a loss of inhibition, which may reflect the development of spasticity. Spinal cord injury results possibly reflect damage to the segmental interneuron pathways. We report a straightforward method to assess changes to spinal circuits controlling wrist flexors after central nervous system lesion.
format	article
author	Stefane A. Aguiar Supriyo Choudhury Hrishikesh Kumar Monica A. Perez Stuart N. Baker
author_facet	Stefane A. Aguiar Supriyo Choudhury Hrishikesh Kumar Monica A. Perez Stuart N. Baker
author_sort	Stefane A. Aguiar
title	Effect of central lesions on a spinal circuit facilitating human wrist flexors
title_short	Effect of central lesions on a spinal circuit facilitating human wrist flexors
title_full	Effect of central lesions on a spinal circuit facilitating human wrist flexors
title_fullStr	Effect of central lesions on a spinal circuit facilitating human wrist flexors
title_full_unstemmed	Effect of central lesions on a spinal circuit facilitating human wrist flexors
title_sort	effect of central lesions on a spinal circuit facilitating human wrist flexors
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/eda2f84221274e3a94a9101631cd33c5
work_keys_str_mv	AT stefaneaaguiar effectofcentrallesionsonaspinalcircuitfacilitatinghumanwristflexors AT supriyochoudhury effectofcentrallesionsonaspinalcircuitfacilitatinghumanwristflexors AT hrishikeshkumar effectofcentrallesionsonaspinalcircuitfacilitatinghumanwristflexors AT monicaaperez effectofcentrallesionsonaspinalcircuitfacilitatinghumanwristflexors AT stuartnbaker effectofcentrallesionsonaspinalcircuitfacilitatinghumanwristflexors
_version_	1718395556453154816

Effect of central lesions on a spinal circuit facilitating human wrist flexors

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