Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up

To date, inconsistent results evaluating the effect of parameters on mechanical thrombectomy (MT) outcomes in stroke-patients have been published. This study aimed to identify the key parameters for functional status after MT in stroke-patients in short and long-term follow-up. Method: The study ana...

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Autores principales:	Anetta Lasek-Bal, Łukasz Binek, Amadeusz Żak, Sebastian Student, Aleksandra Krzan, Przemysław Puz, Wiesław Bal, Urszula Uchwat
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stroke thrombectomy functional state Medicine R
Acceso en línea:	https://doaj.org/article/eda52ac464454695a3d5e2149663d327
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spelling	oai:doaj.org-article:eda52ac464454695a3d5e2149663d3272021-11-11T17:42:17ZClinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up10.3390/jcm102150842077-0383https://doaj.org/article/eda52ac464454695a3d5e2149663d3272021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5084https://doaj.org/toc/2077-0383To date, inconsistent results evaluating the effect of parameters on mechanical thrombectomy (MT) outcomes in stroke-patients have been published. This study aimed to identify the key parameters for functional status after MT in stroke-patients in short and long-term follow-up. Method: The study analysis focused on the relevance of selected clinical and non-clinical parameters to the functional status of the patients after MT. Results: 417 stroke-patients (mean age 67.8 ± 13.2 years) were qualified. Atrial fibrillation, and leukocytosis were significant for the neurological status on the first day of stroke (<i>p</i> = 0.036, and <i>p</i> = 0.0004, respectively). The parameters with the strongest effect on the functional status on day 10 were: age (<i>p</i> = 0.009), NIHSS (<i>p</i> = 0.002), hyperglycemia (<i>p</i> = 0.009), the result in TICI (<i>p</i> = 0.046), and first pass effect (<i>p</i> = 0.043). The parameters with the strongest effect on the functional status on day 365 were: age and NIHSS on the first day of stroke (<i>p</i> = 0.0002 and 0.002, respectively). Leukocytosis and the neurological status at baseline were key parameters associated with ICB after MT (<i>p</i> = 0.007 and <i>p</i> = 0.003, respectively). Conclusions: Age and neurological status in the ultra-acute phase of stroke are crucial for the functional status in short and long-term observations of patients treated with mechanical thrombectomy. Atrial fibrillation, hyperglycemia, and inflammatory state are relevant to the short-term post-stroke functional status. First pass effect and the degree of post-interventional reperfusion are important technical parameters to the short-term functional status. Neurological status and white blood count during the acute phase are associated with a high rate of post-procedural intracranial bleeding.Anetta Lasek-BalŁukasz BinekAmadeusz ŻakSebastian StudentAleksandra KrzanPrzemysław PuzWiesław BalUrszula UchwatMDPI AGarticlestrokethrombectomyfunctional stateMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5084, p 5084 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke thrombectomy functional state Medicine R
spellingShingle	stroke thrombectomy functional state Medicine R Anetta Lasek-Bal Łukasz Binek Amadeusz Żak Sebastian Student Aleksandra Krzan Przemysław Puz Wiesław Bal Urszula Uchwat Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
description	To date, inconsistent results evaluating the effect of parameters on mechanical thrombectomy (MT) outcomes in stroke-patients have been published. This study aimed to identify the key parameters for functional status after MT in stroke-patients in short and long-term follow-up. Method: The study analysis focused on the relevance of selected clinical and non-clinical parameters to the functional status of the patients after MT. Results: 417 stroke-patients (mean age 67.8 ± 13.2 years) were qualified. Atrial fibrillation, and leukocytosis were significant for the neurological status on the first day of stroke (<i>p</i> = 0.036, and <i>p</i> = 0.0004, respectively). The parameters with the strongest effect on the functional status on day 10 were: age (<i>p</i> = 0.009), NIHSS (<i>p</i> = 0.002), hyperglycemia (<i>p</i> = 0.009), the result in TICI (<i>p</i> = 0.046), and first pass effect (<i>p</i> = 0.043). The parameters with the strongest effect on the functional status on day 365 were: age and NIHSS on the first day of stroke (<i>p</i> = 0.0002 and 0.002, respectively). Leukocytosis and the neurological status at baseline were key parameters associated with ICB after MT (<i>p</i> = 0.007 and <i>p</i> = 0.003, respectively). Conclusions: Age and neurological status in the ultra-acute phase of stroke are crucial for the functional status in short and long-term observations of patients treated with mechanical thrombectomy. Atrial fibrillation, hyperglycemia, and inflammatory state are relevant to the short-term post-stroke functional status. First pass effect and the degree of post-interventional reperfusion are important technical parameters to the short-term functional status. Neurological status and white blood count during the acute phase are associated with a high rate of post-procedural intracranial bleeding.
format	article
author	Anetta Lasek-Bal Łukasz Binek Amadeusz Żak Sebastian Student Aleksandra Krzan Przemysław Puz Wiesław Bal Urszula Uchwat
author_facet	Anetta Lasek-Bal Łukasz Binek Amadeusz Żak Sebastian Student Aleksandra Krzan Przemysław Puz Wiesław Bal Urszula Uchwat
author_sort	Anetta Lasek-Bal
title	Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
title_short	Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
title_full	Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
title_fullStr	Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
title_full_unstemmed	Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up
title_sort	clinical and non-clinical determinants of the effect of mechanical thrombectomy and post-stroke functional status of patients in short and long-term follow-up
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eda52ac464454695a3d5e2149663d327
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Clinical and Non-Clinical Determinants of the Effect of Mechanical Thrombectomy and Post-Stroke Functional Status of Patients in Short and Long-Term Follow-Up

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