Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies

The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using me...

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Autores principales:	Gijs D. van Praagh, Pieter H. Nienhuis, Daniel M. de Jong, Melanie Reijrink, Kornelis S. M. van der Geest, Elisabeth Brouwer, Andor W. J. M. Glaudemans, Bhanu Sinha, Antoon T. M. Willemsen, Riemer H. J. A. Slart
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	vasculitis fluorodeoxyglucose F18 positron emission tomography computed tomography standardized uptake values lean body mass Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/eda6dcdbdef84b869ec15149d6d54f71
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spelling	oai:doaj.org-article:eda6dcdbdef84b869ec15149d6d54f712021-11-25T17:20:29ZToward Reliable Uptake Metrics in Large Vessel Vasculitis Studies10.3390/diagnostics111119862075-4418https://doaj.org/article/eda6dcdbdef84b869ec15149d6d54f712021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4418/11/11/1986https://doaj.org/toc/2075-4418The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all <i>p</i> < 0.001) in the blood pool, but no correlations were found between SULs and fat mass (r = −0.25 to −0.15; all <i>p</i> > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.Gijs D. van PraaghPieter H. NienhuisDaniel M. de JongMelanie ReijrinkKornelis S. M. van der GeestElisabeth BrouwerAndor W. J. M. GlaudemansBhanu SinhaAntoon T. M. WillemsenRiemer H. J. A. SlartMDPI AGarticlevasculitisfluorodeoxyglucose F18positron emission tomography computed tomographystandardized uptake valueslean body massMedicine (General)R5-920ENDiagnostics, Vol 11, Iss 1986, p 1986 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vasculitis fluorodeoxyglucose F18 positron emission tomography computed tomography standardized uptake values lean body mass Medicine (General) R5-920
spellingShingle	vasculitis fluorodeoxyglucose F18 positron emission tomography computed tomography standardized uptake values lean body mass Medicine (General) R5-920 Gijs D. van Praagh Pieter H. Nienhuis Daniel M. de Jong Melanie Reijrink Kornelis S. M. van der Geest Elisabeth Brouwer Andor W. J. M. Glaudemans Bhanu Sinha Antoon T. M. Willemsen Riemer H. J. A. Slart Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
description	The aim of this study is to investigate the influence of sex, age, fat mass, fasting blood glucose level (FBGL), and estimated glomerular filtration rate (eGFR) on blood pool activity in patients with large vessel vasculitis (LVV). Blood pool activity was measured in the superior caval vein using mean, maximum, and peak standardized uptake values corrected for body weight (SUVs) and lean body mass (SULs) in 41 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) scans of LVV patients. Sex influence on the blood pool activity was assessed with t-tests, while linear correlation analyses were used for age, fat mass, FBGL, and eGFR. Significantly higher SUVs were found in women compared with men, whereas SULs were similar between sexes. In addition, higher fat mass was associated with increased SUVs (r = 0.56 to 0.65; all <i>p</i> < 0.001) in the blood pool, but no correlations were found between SULs and fat mass (r = −0.25 to −0.15; all <i>p</i> > 0.05). Lower eGFR was associated with a higher FDG blood pool activity for all uptake values. In FDG-PET/CT studies with LVV patients, we recommend using SUL over SUV, while caution is advised in interpreting SUV and SUL measures when patients have impaired kidney function.
format	article
author	Gijs D. van Praagh Pieter H. Nienhuis Daniel M. de Jong Melanie Reijrink Kornelis S. M. van der Geest Elisabeth Brouwer Andor W. J. M. Glaudemans Bhanu Sinha Antoon T. M. Willemsen Riemer H. J. A. Slart
author_facet	Gijs D. van Praagh Pieter H. Nienhuis Daniel M. de Jong Melanie Reijrink Kornelis S. M. van der Geest Elisabeth Brouwer Andor W. J. M. Glaudemans Bhanu Sinha Antoon T. M. Willemsen Riemer H. J. A. Slart
author_sort	Gijs D. van Praagh
title	Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
title_short	Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
title_full	Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
title_fullStr	Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
title_full_unstemmed	Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies
title_sort	toward reliable uptake metrics in large vessel vasculitis studies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/eda6dcdbdef84b869ec15149d6d54f71
work_keys_str_mv	AT gijsdvanpraagh towardreliableuptakemetricsinlargevesselvasculitisstudies AT pieterhnienhuis towardreliableuptakemetricsinlargevesselvasculitisstudies AT danielmdejong towardreliableuptakemetricsinlargevesselvasculitisstudies AT melaniereijrink towardreliableuptakemetricsinlargevesselvasculitisstudies AT kornelissmvandergeest towardreliableuptakemetricsinlargevesselvasculitisstudies AT elisabethbrouwer towardreliableuptakemetricsinlargevesselvasculitisstudies AT andorwjmglaudemans towardreliableuptakemetricsinlargevesselvasculitisstudies AT bhanusinha towardreliableuptakemetricsinlargevesselvasculitisstudies AT antoontmwillemsen towardreliableuptakemetricsinlargevesselvasculitisstudies AT riemerhjaslart towardreliableuptakemetricsinlargevesselvasculitisstudies
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Toward Reliable Uptake Metrics in Large Vessel Vasculitis Studies

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