T-cell activation is an immune correlate of risk in BCG vaccinated infants
BCG vaccine confers only partial protection against tuberculosis. Here the authors show that the risk of tuberculosis infection and progression to disease in BCG-immunized children positively correlates with the frequency of activated HLA-DR+CD4+T cells.
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Nature Portfolio
2016
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oai:doaj.org-article:edab3b0f77064ee189c1a3294bd52daa2021-12-02T14:38:55ZT-cell activation is an immune correlate of risk in BCG vaccinated infants10.1038/ncomms112902041-1723https://doaj.org/article/edab3b0f77064ee189c1a3294bd52daa2016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11290https://doaj.org/toc/2041-1723BCG vaccine confers only partial protection against tuberculosis. Here the authors show that the risk of tuberculosis infection and progression to disease in BCG-immunized children positively correlates with the frequency of activated HLA-DR+CD4+T cells.Helen A. FletcherMargaret A. SnowdenBernard LandryWasima RidaIman SattiStephanie A. HarrisMagali MatsumiyaRachel TannerMatthew K. O’SheaVeerabadran DheenadhayalanLeah BogardusLisa StockdaleLeanne MarsayAgnieszka ChomkaRachel Harrington-KandtZita-Rose Manjaly-ThomasVivek NaranbhaiElena StylianouFatoumatta DarboeAdam Penn-NicholsonElisa NemesMark HatherillGregory HusseyHassan MahomedMichele TamerisJ Bruce McClainThomas G. EvansWillem A. HanekomThomas J. ScribaHelen McShaneNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
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| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Helen A. Fletcher Margaret A. Snowden Bernard Landry Wasima Rida Iman Satti Stephanie A. Harris Magali Matsumiya Rachel Tanner Matthew K. O’Shea Veerabadran Dheenadhayalan Leah Bogardus Lisa Stockdale Leanne Marsay Agnieszka Chomka Rachel Harrington-Kandt Zita-Rose Manjaly-Thomas Vivek Naranbhai Elena Stylianou Fatoumatta Darboe Adam Penn-Nicholson Elisa Nemes Mark Hatherill Gregory Hussey Hassan Mahomed Michele Tameris J Bruce McClain Thomas G. Evans Willem A. Hanekom Thomas J. Scriba Helen McShane T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| description |
BCG vaccine confers only partial protection against tuberculosis. Here the authors show that the risk of tuberculosis infection and progression to disease in BCG-immunized children positively correlates with the frequency of activated HLA-DR+CD4+T cells. |
| format |
article |
| author |
Helen A. Fletcher Margaret A. Snowden Bernard Landry Wasima Rida Iman Satti Stephanie A. Harris Magali Matsumiya Rachel Tanner Matthew K. O’Shea Veerabadran Dheenadhayalan Leah Bogardus Lisa Stockdale Leanne Marsay Agnieszka Chomka Rachel Harrington-Kandt Zita-Rose Manjaly-Thomas Vivek Naranbhai Elena Stylianou Fatoumatta Darboe Adam Penn-Nicholson Elisa Nemes Mark Hatherill Gregory Hussey Hassan Mahomed Michele Tameris J Bruce McClain Thomas G. Evans Willem A. Hanekom Thomas J. Scriba Helen McShane |
| author_facet |
Helen A. Fletcher Margaret A. Snowden Bernard Landry Wasima Rida Iman Satti Stephanie A. Harris Magali Matsumiya Rachel Tanner Matthew K. O’Shea Veerabadran Dheenadhayalan Leah Bogardus Lisa Stockdale Leanne Marsay Agnieszka Chomka Rachel Harrington-Kandt Zita-Rose Manjaly-Thomas Vivek Naranbhai Elena Stylianou Fatoumatta Darboe Adam Penn-Nicholson Elisa Nemes Mark Hatherill Gregory Hussey Hassan Mahomed Michele Tameris J Bruce McClain Thomas G. Evans Willem A. Hanekom Thomas J. Scriba Helen McShane |
| author_sort |
Helen A. Fletcher |
| title |
T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| title_short |
T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| title_full |
T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| title_fullStr |
T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| title_full_unstemmed |
T-cell activation is an immune correlate of risk in BCG vaccinated infants |
| title_sort |
t-cell activation is an immune correlate of risk in bcg vaccinated infants |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/edab3b0f77064ee189c1a3294bd52daa |
| work_keys_str_mv |
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| _version_ |
1718390806240296960 |