Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

Abstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 f...

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Autores principales:	Yung-Tai Chen, Chih-Chin Yu, Hsin-Chih Yeh, Hsiang-Ying Lee, Yuan-Hong Jiang, Yu-Khun Lee, Chia-Hao Kuei, Chia-Chang Wu, Chao-Yuan Huang, Wei-Yu Lin, Cheng Kuang Yang, Yao Chou Tsai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edb0342392fb438b8c253c7d3999360a
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spelling	oai:doaj.org-article:edb0342392fb438b8c253c7d3999360a2021-12-02T14:21:53ZEndoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region10.1038/s41598-021-83495-42045-2322https://doaj.org/article/edb0342392fb438b8c253c7d3999360a2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83495-4https://doaj.org/toc/2045-2322Abstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.Yung-Tai ChenChih-Chin YuHsin-Chih YehHsiang-Ying LeeYuan-Hong JiangYu-Khun LeeChia-Hao KueiChia-Chang WuChao-Yuan HuangWei-Yu LinCheng Kuang YangYao Chou TsaiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
description	Abstract Our aim was to analyze the clinical and survival differences among patients who underwent the two main treatment modalities, endoscopic ablation and radical nephroureterectomy. This study examined all patients who had undergone endoscopic management and RNU between Jul. 1988 and Mar. 2019 from the Taiwan UTUC registry. The inclusion criteria were low stage UTUC in RNU and all cases in endoscopic managed UTUC with a curative intent. The demographic and clinical characteristics were included for analysis. In total, 84 cases in the endoscopic group and 272 cases in the RNU group were enrolled for final analysis. The median follow-up period were 33.5 and 42.0 months in endoscopic and RNU group, respectively (p = 0.082). Comparison of Kaplan–Meier estimated survival curves between groups, the endoscopic group was associated with similar overall survival (OS), cancer specific survival (CSS), and intravesical recurrence free survival (IVRS) but demonstrated inferior disease free survival (DFS) (p = 0.188 for OS, p = 0.493 for CSS and p < 0.001 for DFS). Endoscopic management of UTUC was as safe as RNU in UTUC endemic region.
format	article
author	Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai
author_facet	Yung-Tai Chen Chih-Chin Yu Hsin-Chih Yeh Hsiang-Ying Lee Yuan-Hong Jiang Yu-Khun Lee Chia-Hao Kuei Chia-Chang Wu Chao-Yuan Huang Wei-Yu Lin Cheng Kuang Yang Yao Chou Tsai
author_sort	Yung-Tai Chen
title	Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
title_short	Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
title_full	Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
title_fullStr	Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
title_full_unstemmed	Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
title_sort	endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edb0342392fb438b8c253c7d3999360a
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Endoscopic management versus radical nephroureterectomy for localized upper tract urothelial carcinoma in a high endemic region

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