Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent

Abstract The discovery of compounds and proteins from plants has greatly contributed to modern medicine. Vernonia amygdalina Del. (Compositae) is used by humans and primates for a variety of conditions including parasitic infection. This paper describes the serendipitous discovery that V. amygdalina...

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Autores principales:	Steven Lynham, Fabio Grundland Freile, Natasha M. Puri, Nicola O’Reilly, Graham H. Mitchell, Timothy N. C. Wells, Merlin Willcox, Richard Beatson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edb0bc195dac42f384074befbd859da7
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spelling	oai:doaj.org-article:edb0bc195dac42f384074befbd859da72021-12-02T14:20:43ZIdentification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent10.1038/s41598-021-87454-x2045-2322https://doaj.org/article/edb0bc195dac42f384074befbd859da72021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87454-xhttps://doaj.org/toc/2045-2322Abstract The discovery of compounds and proteins from plants has greatly contributed to modern medicine. Vernonia amygdalina Del. (Compositae) is used by humans and primates for a variety of conditions including parasitic infection. This paper describes the serendipitous discovery that V. amygdalina extract was able to bind to, and functionally inhibit, active TGFβ1. The binding agent was isolated and identified as chlorophyll a-b binding protein AB96. Given that active TGFβ1 contributes to the pathology of many infectious diseases, inhibiting these processes may explain some of the benefits associated with the ingestion of this species. This is the first plant-derived cytokine-neutralizing protein to be described and paves the way for further such discoveries.Steven LynhamFabio Grundland FreileNatasha M. PuriNicola O’ReillyGraham H. MitchellTimothy N. C. WellsMerlin WillcoxRichard BeatsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Steven Lynham Fabio Grundland Freile Natasha M. Puri Nicola O’Reilly Graham H. Mitchell Timothy N. C. Wells Merlin Willcox Richard Beatson Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
description	Abstract The discovery of compounds and proteins from plants has greatly contributed to modern medicine. Vernonia amygdalina Del. (Compositae) is used by humans and primates for a variety of conditions including parasitic infection. This paper describes the serendipitous discovery that V. amygdalina extract was able to bind to, and functionally inhibit, active TGFβ1. The binding agent was isolated and identified as chlorophyll a-b binding protein AB96. Given that active TGFβ1 contributes to the pathology of many infectious diseases, inhibiting these processes may explain some of the benefits associated with the ingestion of this species. This is the first plant-derived cytokine-neutralizing protein to be described and paves the way for further such discoveries.
format	article
author	Steven Lynham Fabio Grundland Freile Natasha M. Puri Nicola O’Reilly Graham H. Mitchell Timothy N. C. Wells Merlin Willcox Richard Beatson
author_facet	Steven Lynham Fabio Grundland Freile Natasha M. Puri Nicola O’Reilly Graham H. Mitchell Timothy N. C. Wells Merlin Willcox Richard Beatson
author_sort	Steven Lynham
title	Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
title_short	Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
title_full	Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
title_fullStr	Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
title_full_unstemmed	Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent
title_sort	identification of chlorophyll a-b binding protein ab96 as a novel tgfβ1 neutralizing agent
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edb0bc195dac42f384074befbd859da7
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Identification of chlorophyll a-b binding protein AB96 as a novel TGFβ1 neutralizing agent

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