Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

How ubiquitination affects the proteins it modifies varies according to the type of linkage between ubiquitin moieties. Here, Liuet al. show how yeast Udf2p promotes K48 linkage formation onto K29-linked chains to generate branched K29-K48 ubiquitin chains that target its substrate to the proteasome...

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Autores principales:	Chao Liu, Weixiao Liu, Yihong Ye, Wei Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/edb101d698df47828af07b5e22ed4a87
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spelling	oai:doaj.org-article:edb101d698df47828af07b5e22ed4a872021-12-02T17:06:08ZUfd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains10.1038/ncomms142742041-1723https://doaj.org/article/edb101d698df47828af07b5e22ed4a872017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14274https://doaj.org/toc/2041-1723How ubiquitination affects the proteins it modifies varies according to the type of linkage between ubiquitin moieties. Here, Liuet al. show how yeast Udf2p promotes K48 linkage formation onto K29-linked chains to generate branched K29-K48 ubiquitin chains that target its substrate to the proteasome.Chao LiuWeixiao LiuYihong YeWei LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Chao Liu Weixiao Liu Yihong Ye Wei Li Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
description	How ubiquitination affects the proteins it modifies varies according to the type of linkage between ubiquitin moieties. Here, Liuet al. show how yeast Udf2p promotes K48 linkage formation onto K29-linked chains to generate branched K29-K48 ubiquitin chains that target its substrate to the proteasome.
format	article
author	Chao Liu Weixiao Liu Yihong Ye Wei Li
author_facet	Chao Liu Weixiao Liu Yihong Ye Wei Li
author_sort	Chao Liu
title	Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
title_short	Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
title_full	Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
title_fullStr	Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
title_full_unstemmed	Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
title_sort	ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/edb101d698df47828af07b5e22ed4a87
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Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains

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