A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi

Objective: To assess the effect of diuretics with shockwave lithotripsy (SWL) on the treatment of renal and upper ureteric calculi. Patients and methods: Adult patients with a solitary non-obstructive radio-opaque renal or upper ureteric calculus with normal renal function were included. They were p...

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Autores principales:	Sagar Sabharwal, L. Jeyaseelan, Arabind Panda, Lionel Gnanaraj, Nitin S. Kekre, Antony Devasia
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2017
Materias:	Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/edb4081a5366449a85d8f31204e4c0ec
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spelling	oai:doaj.org-article:edb4081a5366449a85d8f31204e4c0ec2021-12-02T10:50:51ZA prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi2090-598X10.1016/j.aju.2017.04.003https://doaj.org/article/edb4081a5366449a85d8f31204e4c0ec2017-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2090598X17300682https://doaj.org/toc/2090-598XObjective: To assess the effect of diuretics with shockwave lithotripsy (SWL) on the treatment of renal and upper ureteric calculi. Patients and methods: Adult patients with a solitary non-obstructive radio-opaque renal or upper ureteric calculus with normal renal function were included. They were prospectively randomised to receive either SWL with placebo or SWL with diuretics (40 mg parenteral furosemide) in a double-blind manner with a sample size of 48 patients in each arm. The primary outcomes were the SWL success and failure rates. The secondary outcomes were the number of shocks and sessions. Results: Complete fragmentation was achieved in 89.6% of the patients in the furosemide arm as compared to 81.3% in the placebo arm. Clearance was achieved in 77.1% of the patients in the furosemide arm as compared to 70.8% in the placebo arm. The number of shocks and the number of sessions were higher in the placebo arm. These differences were not statistically significant. Conclusion: The use of diuretics along with SWL treatment of renal and upper ureteric calculi does not show a statistically significant improvement in fragmentation or clearance. Keywords: Diuretics, Renal calculi, Shockwave lithotripsy, Ureteric calculiSagar SabharwalL. JeyaseelanArabind PandaLionel GnanarajNitin S. KekreAntony DevasiaTaylor & Francis GrouparticleDiseases of the genitourinary system. UrologyRC870-923ENArab Journal of Urology, Vol 15, Iss 4, Pp 289-293 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Diseases of the genitourinary system. Urology RC870-923 Sagar Sabharwal L. Jeyaseelan Arabind Panda Lionel Gnanaraj Nitin S. Kekre Antony Devasia A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
description	Objective: To assess the effect of diuretics with shockwave lithotripsy (SWL) on the treatment of renal and upper ureteric calculi. Patients and methods: Adult patients with a solitary non-obstructive radio-opaque renal or upper ureteric calculus with normal renal function were included. They were prospectively randomised to receive either SWL with placebo or SWL with diuretics (40 mg parenteral furosemide) in a double-blind manner with a sample size of 48 patients in each arm. The primary outcomes were the SWL success and failure rates. The secondary outcomes were the number of shocks and sessions. Results: Complete fragmentation was achieved in 89.6% of the patients in the furosemide arm as compared to 81.3% in the placebo arm. Clearance was achieved in 77.1% of the patients in the furosemide arm as compared to 70.8% in the placebo arm. The number of shocks and the number of sessions were higher in the placebo arm. These differences were not statistically significant. Conclusion: The use of diuretics along with SWL treatment of renal and upper ureteric calculi does not show a statistically significant improvement in fragmentation or clearance. Keywords: Diuretics, Renal calculi, Shockwave lithotripsy, Ureteric calculi
format	article
author	Sagar Sabharwal L. Jeyaseelan Arabind Panda Lionel Gnanaraj Nitin S. Kekre Antony Devasia
author_facet	Sagar Sabharwal L. Jeyaseelan Arabind Panda Lionel Gnanaraj Nitin S. Kekre Antony Devasia
author_sort	Sagar Sabharwal
title	A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
title_short	A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
title_full	A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
title_fullStr	A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
title_full_unstemmed	A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
title_sort	prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi
publisher	Taylor & Francis Group
publishDate	2017
url	https://doaj.org/article/edb4081a5366449a85d8f31204e4c0ec
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A prospective randomised double-blind placebo-controlled trial to assess the effect of diuretics on shockwave lithotripsy of calculi

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