Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules

Abstract In shear wave elastography (SWE) studies, the optimal cutoff value of Young’s modulus for the diagnosis of benign and malignant thyroid nodules varies greatly, which affects the clinical application of the method. The objective of this study was to evaluate the influence of thyroid nodule s...

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Autores principales:	Huizhan Li, Chunsong Kang, Jiping Xue, Liwei Jing, Junwang Miao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edb595496e414c218b7566d3bfa4407d
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spelling	oai:doaj.org-article:edb595496e414c218b7566d3bfa4407d2021-11-08T10:52:33ZInfluence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules10.1038/s41598-021-01114-82045-2322https://doaj.org/article/edb595496e414c218b7566d3bfa4407d2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01114-8https://doaj.org/toc/2045-2322Abstract In shear wave elastography (SWE) studies, the optimal cutoff value of Young’s modulus for the diagnosis of benign and malignant thyroid nodules varies greatly, which affects the clinical application of the method. The objective of this study was to evaluate the influence of thyroid nodule size on the clinical diagnostic efficacy of SWE. A total of 356 thyroid nodules of 280 patients were divided into three groups according to size (Group A: ≤ 1 cm; Group B: 1–2 cm; Group C: ≥ 2 cm). SWE was used to measure the maximum Young's modulus (Emax) values of all thyroid nodules. Receiver operating characteristic (ROC) curves were drawn with pathological results as the gold standard. For all nodules, the optimal cutoff value of Emax in SWE for diagnosing malignant thyroid nodules was 36.2 kPa. The sensitivity and specificity were 76.5% and 78.4%, respectively. Groups A, B, and C had different optimal Emax cutoff values of 33.7 kPa, 37.7 kPa, and 55.1 kPa, respectively. The area under the ROC curve (AUC) values of Groups A, B, and C (0.844, 0.886, and 0.935, respectively) were all greater than the values for all lesions (0.830). The specificity values of Groups A, B, and C (86.4%, 82.6%, and 88.2%, respectively) were all increased, and the sensitivity values of Groups B and C (89.7% and 96.4%, respectively) were also increased compared with the values for all lesions. Thyroid nodule size affects the optimal Emax cutoff value of SWE. We suggest that different cutoff values be used to diagnose benign and malignant thyroid nodules according to lesion size.Huizhan LiChunsong KangJiping XueLiwei JingJunwang MiaoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Huizhan Li Chunsong Kang Jiping Xue Liwei Jing Junwang Miao Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
description	Abstract In shear wave elastography (SWE) studies, the optimal cutoff value of Young’s modulus for the diagnosis of benign and malignant thyroid nodules varies greatly, which affects the clinical application of the method. The objective of this study was to evaluate the influence of thyroid nodule size on the clinical diagnostic efficacy of SWE. A total of 356 thyroid nodules of 280 patients were divided into three groups according to size (Group A: ≤ 1 cm; Group B: 1–2 cm; Group C: ≥ 2 cm). SWE was used to measure the maximum Young's modulus (Emax) values of all thyroid nodules. Receiver operating characteristic (ROC) curves were drawn with pathological results as the gold standard. For all nodules, the optimal cutoff value of Emax in SWE for diagnosing malignant thyroid nodules was 36.2 kPa. The sensitivity and specificity were 76.5% and 78.4%, respectively. Groups A, B, and C had different optimal Emax cutoff values of 33.7 kPa, 37.7 kPa, and 55.1 kPa, respectively. The area under the ROC curve (AUC) values of Groups A, B, and C (0.844, 0.886, and 0.935, respectively) were all greater than the values for all lesions (0.830). The specificity values of Groups A, B, and C (86.4%, 82.6%, and 88.2%, respectively) were all increased, and the sensitivity values of Groups B and C (89.7% and 96.4%, respectively) were also increased compared with the values for all lesions. Thyroid nodule size affects the optimal Emax cutoff value of SWE. We suggest that different cutoff values be used to diagnose benign and malignant thyroid nodules according to lesion size.
format	article
author	Huizhan Li Chunsong Kang Jiping Xue Liwei Jing Junwang Miao
author_facet	Huizhan Li Chunsong Kang Jiping Xue Liwei Jing Junwang Miao
author_sort	Huizhan Li
title	Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
title_short	Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
title_full	Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
title_fullStr	Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
title_full_unstemmed	Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
title_sort	influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edb595496e414c218b7566d3bfa4407d
work_keys_str_mv	AT huizhanli influenceoflesionsizeonshearwaveelastographyinthediagnosisofbenignandmalignantthyroidnodules AT chunsongkang influenceoflesionsizeonshearwaveelastographyinthediagnosisofbenignandmalignantthyroidnodules AT jipingxue influenceoflesionsizeonshearwaveelastographyinthediagnosisofbenignandmalignantthyroidnodules AT liweijing influenceoflesionsizeonshearwaveelastographyinthediagnosisofbenignandmalignantthyroidnodules AT junwangmiao influenceoflesionsizeonshearwaveelastographyinthediagnosisofbenignandmalignantthyroidnodules
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Influence of lesion size on shear wave elastography in the diagnosis of benign and malignant thyroid nodules

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