The early metabolomic response of adipose tissue during acute cold exposure in mice

Abstract To maintain core body temperature in cold conditions, mammals activate a complex multi-organ metabolic response for heat production. White adipose tissue (WAT) primarily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold exposure to generate heat fro...

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Autores principales:	Xiyuan Lu, Ashley Solmonson, Alessia Lodi, Sara M. Nowinski, Enrique Sentandreu, Christopher L. Riley, Edward M. Mills, Stefano Tiziani
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edb7f29ff306400a90df6841e1cd6c42
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spelling	oai:doaj.org-article:edb7f29ff306400a90df6841e1cd6c422021-12-02T15:05:37ZThe early metabolomic response of adipose tissue during acute cold exposure in mice10.1038/s41598-017-03108-x2045-2322https://doaj.org/article/edb7f29ff306400a90df6841e1cd6c422017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03108-xhttps://doaj.org/toc/2045-2322Abstract To maintain core body temperature in cold conditions, mammals activate a complex multi-organ metabolic response for heat production. White adipose tissue (WAT) primarily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold exposure to generate heat from nutrients. Both BAT and WAT undergo specific metabolic changes during acute cold exposure. Here, we use an untargeted metabolomics approach to characterize the initial metabolic response to cold exposure in multiple adipose tissue depots in mice. Results demonstrate dramatically distinct metabolic responses during cold exposure in BAT and WAT. Amino acids, nucleotide pathways, and metabolites involved in redox regulation were greatly affected 4 hours post-exposure in BAT, while no polar metabolites were observed to significantly change in WAT depots up to 6 hours post exposure. Lipid metabolism was activated early (2 hours) in both BAT and the subcutaneous WAT depots, with the most striking change being observed in the modulation of diglyceride and monoglyceride levels in BAT. Overall, these data provide a timeline of global thermogenic metabolism in adipose depots during acute cold exposure. We have highlighted differences in visceral and subcutaneous WAT thermogenic metabolism and demonstrate the distinct metabolism of BAT during cold exposure.Xiyuan LuAshley SolmonsonAlessia LodiSara M. NowinskiEnrique SentandreuChristopher L. RileyEdward M. MillsStefano TizianiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiyuan Lu Ashley Solmonson Alessia Lodi Sara M. Nowinski Enrique Sentandreu Christopher L. Riley Edward M. Mills Stefano Tiziani The early metabolomic response of adipose tissue during acute cold exposure in mice
description	Abstract To maintain core body temperature in cold conditions, mammals activate a complex multi-organ metabolic response for heat production. White adipose tissue (WAT) primarily functions as an energy reservoir, while brown adipose tissue (BAT) is activated during cold exposure to generate heat from nutrients. Both BAT and WAT undergo specific metabolic changes during acute cold exposure. Here, we use an untargeted metabolomics approach to characterize the initial metabolic response to cold exposure in multiple adipose tissue depots in mice. Results demonstrate dramatically distinct metabolic responses during cold exposure in BAT and WAT. Amino acids, nucleotide pathways, and metabolites involved in redox regulation were greatly affected 4 hours post-exposure in BAT, while no polar metabolites were observed to significantly change in WAT depots up to 6 hours post exposure. Lipid metabolism was activated early (2 hours) in both BAT and the subcutaneous WAT depots, with the most striking change being observed in the modulation of diglyceride and monoglyceride levels in BAT. Overall, these data provide a timeline of global thermogenic metabolism in adipose depots during acute cold exposure. We have highlighted differences in visceral and subcutaneous WAT thermogenic metabolism and demonstrate the distinct metabolism of BAT during cold exposure.
format	article
author	Xiyuan Lu Ashley Solmonson Alessia Lodi Sara M. Nowinski Enrique Sentandreu Christopher L. Riley Edward M. Mills Stefano Tiziani
author_facet	Xiyuan Lu Ashley Solmonson Alessia Lodi Sara M. Nowinski Enrique Sentandreu Christopher L. Riley Edward M. Mills Stefano Tiziani
author_sort	Xiyuan Lu
title	The early metabolomic response of adipose tissue during acute cold exposure in mice
title_short	The early metabolomic response of adipose tissue during acute cold exposure in mice
title_full	The early metabolomic response of adipose tissue during acute cold exposure in mice
title_fullStr	The early metabolomic response of adipose tissue during acute cold exposure in mice
title_full_unstemmed	The early metabolomic response of adipose tissue during acute cold exposure in mice
title_sort	early metabolomic response of adipose tissue during acute cold exposure in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/edb7f29ff306400a90df6841e1cd6c42
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The early metabolomic response of adipose tissue during acute cold exposure in mice

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