Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells

Experimental and clinical studies have shown that the technique of deep brain stimulation (DBS) plays a potential role in the regulation of Alzheimer’s disease (AD), yet it still desires for ongoing studies including clinical trials, theoretical approach and action mechanism. In this work, we develo...

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Autores principales:	XiaoLi Yang, RuiXi Zhang, ZhongKui Sun, Jürgen Kurths
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	neurocomputation power spectrum analysis thalamo-cortico-thalamic model deep brain stimulation Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/edb86f71e9e34624af20057c1c761613
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spelling	oai:doaj.org-article:edb86f71e9e34624af20057c1c7616132021-11-08T04:55:00ZControlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells1662-518810.3389/fncom.2021.636770https://doaj.org/article/edb86f71e9e34624af20057c1c7616132021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fncom.2021.636770/fullhttps://doaj.org/toc/1662-5188Experimental and clinical studies have shown that the technique of deep brain stimulation (DBS) plays a potential role in the regulation of Alzheimer’s disease (AD), yet it still desires for ongoing studies including clinical trials, theoretical approach and action mechanism. In this work, we develop a modified thalamo-cortico-thalamic (TCT) model associated with AD to explore the therapeutic effects of DBS on AD from the perspective of neurocomputation. First, the neuropathological state of AD resulting from synapse loss is mimicked by decreasing the synaptic connectivity strength from the Inter-Neurons (IN) neuron population to the Thalamic Relay Cells (TRC) neuron population. Under such AD condition, a specific deep brain stimulation voltage is then implanted into the neural nucleus of TRC in this TCT model. The symptom of AD is found significantly relieved by means of power spectrum analysis and nonlinear dynamical analysis. Furthermore, the therapeutic effects of DBS on AD are systematically examined in different parameter space of DBS. The results demonstrate that the controlling effect of DBS on AD can be efficient by appropriately tuning the key parameters of DBS including amplitude A, period P and duration D. This work highlights the critical role of thalamus stimulation for brain disease, and provides a theoretical basis for future experimental and clinical studies in treating AD.XiaoLi YangRuiXi ZhangZhongKui SunJürgen KurthsJürgen KurthsJürgen KurthsFrontiers Media S.A.articleneurocomputationpower spectrum analysisthalamo-cortico-thalamic modeldeep brain stimulationAlzheimer’s diseaseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Computational Neuroscience, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	neurocomputation power spectrum analysis thalamo-cortico-thalamic model deep brain stimulation Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	neurocomputation power spectrum analysis thalamo-cortico-thalamic model deep brain stimulation Alzheimer’s disease Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 XiaoLi Yang RuiXi Zhang ZhongKui Sun Jürgen Kurths Jürgen Kurths Jürgen Kurths Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
description	Experimental and clinical studies have shown that the technique of deep brain stimulation (DBS) plays a potential role in the regulation of Alzheimer’s disease (AD), yet it still desires for ongoing studies including clinical trials, theoretical approach and action mechanism. In this work, we develop a modified thalamo-cortico-thalamic (TCT) model associated with AD to explore the therapeutic effects of DBS on AD from the perspective of neurocomputation. First, the neuropathological state of AD resulting from synapse loss is mimicked by decreasing the synaptic connectivity strength from the Inter-Neurons (IN) neuron population to the Thalamic Relay Cells (TRC) neuron population. Under such AD condition, a specific deep brain stimulation voltage is then implanted into the neural nucleus of TRC in this TCT model. The symptom of AD is found significantly relieved by means of power spectrum analysis and nonlinear dynamical analysis. Furthermore, the therapeutic effects of DBS on AD are systematically examined in different parameter space of DBS. The results demonstrate that the controlling effect of DBS on AD can be efficient by appropriately tuning the key parameters of DBS including amplitude A, period P and duration D. This work highlights the critical role of thalamus stimulation for brain disease, and provides a theoretical basis for future experimental and clinical studies in treating AD.
format	article
author	XiaoLi Yang RuiXi Zhang ZhongKui Sun Jürgen Kurths Jürgen Kurths Jürgen Kurths
author_facet	XiaoLi Yang RuiXi Zhang ZhongKui Sun Jürgen Kurths Jürgen Kurths Jürgen Kurths
author_sort	XiaoLi Yang
title	Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
title_short	Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
title_full	Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
title_fullStr	Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
title_full_unstemmed	Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells
title_sort	controlling alzheimer’s disease through the deep brain stimulation to thalamic relay cells
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/edb86f71e9e34624af20057c1c761613
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Controlling Alzheimer’s Disease Through the Deep Brain Stimulation to Thalamic Relay Cells

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