Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>
ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical t...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
American Society for Microbiology
2018
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| Subjects: | |
| Online Access: | https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8 |
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