Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

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Deciphering the Evolution of Cephalosporin Resistance to Ceftolozane-Tazobactam in <named-content content-type="genus-species">Pseudomonas aeruginosa</named-content>

ABSTRACT Pseudomonas aeruginosa produces a class C β-lactamase (e.g., PDC-3) that robustly hydrolyzes early generation cephalosporins often at the diffusion limit; therefore, bacteria possessing these β-lactamases are resistant to many β-lactam antibiotics. In response to this significant clinical t...

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Auteurs principaux:	Melissa D. Barnes, Magdalena A. Taracila, Joseph D. Rutter, Christopher R. Bethel, Ioannis Galdadas, Andrea M. Hujer, Emilia Caselli, Fabio Prati, John P. Dekker, Krisztina M. Papp-Wallace, Shozeb Haider, Robert A. Bonomo
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2018
Sujets:	AmpC PDC-3 antibiotic resistance beta-lactam beta-lactamase ceftolozane Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/edb8dbd7a6454ff080c0150b5085a0a8
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