Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids

Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexe...

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Autores principales:	S. S. Khizrieva, E. V. Vetrova, S. N. Borisenko, E. V. Maksimenko, N. I. Borisenko
Formato:	article
Lenguaje:	EN RU
Publicado:	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina 2021
Materias:	camphecene quercetin rutin antiviral activity supramolecular complexes Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/edb8f0c46cc64c2ba49378fa127cefbb
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spelling	oai:doaj.org-article:edb8f0c46cc64c2ba49378fa127cefbb2021-12-01T05:53:11ZSynthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids2411-141410.15826/chimtech.2021.8.2.02https://doaj.org/article/edb8f0c46cc64c2ba49378fa127cefbb2021-04-01T00:00:00Zhttps://journals.urfu.ru/index.php/chimtech/article/view/4978https://doaj.org/toc/2411-1414Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery.S. S. KhizrievaE. V. VetrovaS. N. BorisenkoE. V. MaksimenkoN. I. BorisenkoUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina articlecamphecenequercetinrutinantiviral activitysupramolecular complexesChemistryQD1-999ENRUChimica Techno Acta, Vol 8, Iss 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	camphecene quercetin rutin antiviral activity supramolecular complexes Chemistry QD1-999
spellingShingle	camphecene quercetin rutin antiviral activity supramolecular complexes Chemistry QD1-999 S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
description	Traditionally, glycyrrhizic acid has been used to form polydentate complexes. For the first time in the presented paper, the complexation of the Plant’s Flavonoids (Quercetin (Qu) and its glycoside - Rutin (Rut)) with the novel Russian antiviral drug Camphecene (Camph) was investigated. The complexes obtained at different molar ratios were studied using UV/Vis spectroscopy. Formation of the host: guest complexes were registered: Qu and Rut molecular complexes (Camph+2Qu; Camph+2Rut) with a stability constant K = 3.3·108 M-2. Comparison of the binding constants of the obtained complexes shows that the efficiency of Camphecene complexation with the participation of flavonoids is more efficient than with the participation of triterpenoids. Besides, it was found that the complexes of Camphecene with the quercetin and rutin are soluble in water, in contrast to the complexes with triterpenoids, which makes it possible to increase the bioavailability of both Camphecene and flavonoids. The obtained results demonstrate the high potential of flavonoids Qu and Rut to the development of novel pharmaceutical forms using the example of Camphecene in the form of molecular complexes, as the novel forms of delivery.
format	article
author	S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko
author_facet	S. S. Khizrieva E. V. Vetrova S. N. Borisenko E. V. Maksimenko N. I. Borisenko
author_sort	S. S. Khizrieva
title	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
title_short	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
title_full	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
title_fullStr	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
title_full_unstemmed	Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids
title_sort	synthesis and study of complexes of the novel russian antiviral drug camphecene with plant’s flavonoids
publisher	Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
publishDate	2021
url	https://doaj.org/article/edb8f0c46cc64c2ba49378fa127cefbb
work_keys_str_mv	AT sskhizrieva synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT evvetrova synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT snborisenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT evmaksimenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids AT niborisenko synthesisandstudyofcomplexesofthenovelrussianantiviraldrugcamphecenewithplantsflavonoids
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Synthesis and study of complexes of the novel Russian antiviral drug Camphecene with Plant’s Flavonoids

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