Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S

Yaping Li,1–3 Lu An,1–3 Jiaomin Lin,1–3 Qiwei Tian,1–3 Shiping Yang1–31Key Laboratory of Resource Chemistry of the Ministry of Education; 2The Shanghai Key Laboratory of Rare Earth Functional Materials; 3The Shanghai Municipal Education Committee Key...

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Main Authors:	Li Y, An L, Lin J, Tian Q, Yang S
Format:	article
Language:	EN
Published:	Dove Medical Press 2019
Subjects:	tumor microenvironment smart nanomedicine agents theranostic agents smart nanoprobes smart nanocarrier Medicine (General) R5-920
Online Access:	https://doaj.org/article/edb93de9d0b945b9b99935e4c09b743d
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spelling	oai:doaj.org-article:edb93de9d0b945b9b99935e4c09b743d2021-12-02T02:50:31ZSmart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S1178-2013https://doaj.org/article/edb93de9d0b945b9b99935e4c09b743d2019-07-01T00:00:00Zhttps://www.dovepress.com/smart-nanomedicine-agents-for-cancer-triggered-by-ph-glutathione-h2o2--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yaping Li,1–3 Lu An,1–3 Jiaomin Lin,1–3 Qiwei Tian,1–3 Shiping Yang1–31Key Laboratory of Resource Chemistry of the Ministry of Education; 2The Shanghai Key Laboratory of Rare Earth Functional Materials; 3The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, People’s Republic of ChinaAbstract: Effective tumor diagnosis and therapy have always been a significant but challenging issue. Although nanomedicine has shown great potential for improving the outcomes of tumor diagnosis and therapy, the nonspecial targeted distribution of nanomedicine agents in the whole body causes a low diagnosis signal-to-noise ratio and a potential risk of systemic toxicity. Recently, the development of smart nanomedicine agents with diagnosis and therapy functions that can only be activated by the tumor microenvironment (TME) is regarded as an effective strategy to improve the theranostic sensitivity and selectivity, as well as reduce the potential side effects during treatment. This article will introduce and summarize the latest achievements in the design and fabrication of TME-responsive smart nanomedicine agents, and highlight their prospects for enhancing tumor diagnosis and therapy.Keywords: tumor microenvironment, smart nanomedicine agents, theranostic agents, smart nanoprobes, smart nanocarriersLi YAn LLin JTian QYang SDove Medical Pressarticletumor microenvironmentsmart nanomedicine agentstheranostic agentssmart nanoprobessmart nanocarrierMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 5729-5749 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	tumor microenvironment smart nanomedicine agents theranostic agents smart nanoprobes smart nanocarrier Medicine (General) R5-920
spellingShingle	tumor microenvironment smart nanomedicine agents theranostic agents smart nanoprobes smart nanocarrier Medicine (General) R5-920 Li Y An L Lin J Tian Q Yang S Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
description	Yaping Li,1–3 Lu An,1–3 Jiaomin Lin,1–3 Qiwei Tian,1–3 Shiping Yang1–31Key Laboratory of Resource Chemistry of the Ministry of Education; 2The Shanghai Key Laboratory of Rare Earth Functional Materials; 3The Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, Shanghai Normal University, Shanghai 200234, People’s Republic of ChinaAbstract: Effective tumor diagnosis and therapy have always been a significant but challenging issue. Although nanomedicine has shown great potential for improving the outcomes of tumor diagnosis and therapy, the nonspecial targeted distribution of nanomedicine agents in the whole body causes a low diagnosis signal-to-noise ratio and a potential risk of systemic toxicity. Recently, the development of smart nanomedicine agents with diagnosis and therapy functions that can only be activated by the tumor microenvironment (TME) is regarded as an effective strategy to improve the theranostic sensitivity and selectivity, as well as reduce the potential side effects during treatment. This article will introduce and summarize the latest achievements in the design and fabrication of TME-responsive smart nanomedicine agents, and highlight their prospects for enhancing tumor diagnosis and therapy.Keywords: tumor microenvironment, smart nanomedicine agents, theranostic agents, smart nanoprobes, smart nanocarriers
format	article
author	Li Y An L Lin J Tian Q Yang S
author_facet	Li Y An L Lin J Tian Q Yang S
author_sort	Li Y
title	Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
title_short	Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
title_full	Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
title_fullStr	Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
title_full_unstemmed	Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S
title_sort	smart nanomedicine agents for cancer, triggered by ph, glutathione, h2o2, or h2s
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/edb93de9d0b945b9b99935e4c09b743d
work_keys_str_mv	AT liy smartnanomedicineagentsforcancertriggeredbyphglutathioneh2o2orh2s AT anl smartnanomedicineagentsforcancertriggeredbyphglutathioneh2o2orh2s AT linj smartnanomedicineagentsforcancertriggeredbyphglutathioneh2o2orh2s AT tianq smartnanomedicineagentsforcancertriggeredbyphglutathioneh2o2orh2s AT yangs smartnanomedicineagentsforcancertriggeredbyphglutathioneh2o2orh2s
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Smart nanomedicine agents for cancer, triggered by pH, glutathione, H2O2, or H2S

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