Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.

<h4>Purpose</h4>To evaluate the value of DWI in detecting the lesions of pre- and post-radiofrequency ablation (RFA) of the rabbit liver VX2 tumors.<h4>Materials and methods</h4>Twenty-two New Zealand White rabbits were tested. The protocol was approved by the Committee on th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yubao Liu, Ligong Lu, Haosheng Jin, Xiaoming Chen, Zhonglin Zhang, Zaiyi Liu, Changhong Liang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edb997b4e70c4b0981a0b326e5f77f71
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:edb997b4e70c4b0981a0b326e5f77f71
record_format	dspace
spelling	oai:doaj.org-article:edb997b4e70c4b0981a0b326e5f77f712021-11-25T06:05:36ZRadiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.1932-620310.1371/journal.pone.0104239https://doaj.org/article/edb997b4e70c4b0981a0b326e5f77f712014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25102074/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To evaluate the value of DWI in detecting the lesions of pre- and post-radiofrequency ablation (RFA) of the rabbit liver VX2 tumors.<h4>Materials and methods</h4>Twenty-two New Zealand White rabbits were tested. The protocol was approved by the Committee on the Ethics of Animal Experiments. Twenty separate tumor fragments were implanted into the livers of 20 rabbits, the liver was exposed by performing midline laparotomy. 3.0T MR DWI (b = 0, 200, 400, 600, 800,1000 s/mm2) were performed 14-21 days after tumor implantation (mean, 17 days) in the 18 tumor-bearing animals. Then RFA was performed in the 18 tumor-bearing animals and in the two healthy animals. 3.0T MR DWI was performed 7-10 days after RFA (mean, 8 days). Pathology exam was performed immediately after the completion of post- RFA MR imaging. Analyzing the features of MRI and ADC values in the pre- and post- RFA lesions of the VX2 tumors, and histopathologic results were compared with imaging findings.<h4>Results</h4>The difference of ADC value between viable tumor and normal liver parenchyma was significant (P<.001). After RFA, when b = 200, 400, 600, 800, 1000 s/mm2, the differences of ADC values of viable tumor, granulation tissue, necrosis, normal liver parenchyma were significant (P<.001). At the time the animals were sacrificed after RFA and MR imaging, histopathologic results of local viable tumors were found in 9 (50%) of the 18 treated tumors. Macroscopic viable tumors were found at the RFA sites in 3 (17%), all 3 macroscopic viable tumors were visualized at the periphery of the RFA areas.<h4>Conclusions</h4>3.0T MR DWI can be used to follow up the progress of the RFA lesion, it is useful in detecting different tissues after RFA, and it is valuable in the further clinical research.Yubao LiuLigong LuHaosheng JinXiaoming ChenZhonglin ZhangZaiyi LiuChanghong LiangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e104239 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yubao Liu Ligong Lu Haosheng Jin Xiaoming Chen Zhonglin Zhang Zaiyi Liu Changhong Liang Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
description	<h4>Purpose</h4>To evaluate the value of DWI in detecting the lesions of pre- and post-radiofrequency ablation (RFA) of the rabbit liver VX2 tumors.<h4>Materials and methods</h4>Twenty-two New Zealand White rabbits were tested. The protocol was approved by the Committee on the Ethics of Animal Experiments. Twenty separate tumor fragments were implanted into the livers of 20 rabbits, the liver was exposed by performing midline laparotomy. 3.0T MR DWI (b = 0, 200, 400, 600, 800,1000 s/mm2) were performed 14-21 days after tumor implantation (mean, 17 days) in the 18 tumor-bearing animals. Then RFA was performed in the 18 tumor-bearing animals and in the two healthy animals. 3.0T MR DWI was performed 7-10 days after RFA (mean, 8 days). Pathology exam was performed immediately after the completion of post- RFA MR imaging. Analyzing the features of MRI and ADC values in the pre- and post- RFA lesions of the VX2 tumors, and histopathologic results were compared with imaging findings.<h4>Results</h4>The difference of ADC value between viable tumor and normal liver parenchyma was significant (P<.001). After RFA, when b = 200, 400, 600, 800, 1000 s/mm2, the differences of ADC values of viable tumor, granulation tissue, necrosis, normal liver parenchyma were significant (P<.001). At the time the animals were sacrificed after RFA and MR imaging, histopathologic results of local viable tumors were found in 9 (50%) of the 18 treated tumors. Macroscopic viable tumors were found at the RFA sites in 3 (17%), all 3 macroscopic viable tumors were visualized at the periphery of the RFA areas.<h4>Conclusions</h4>3.0T MR DWI can be used to follow up the progress of the RFA lesion, it is useful in detecting different tissues after RFA, and it is valuable in the further clinical research.
format	article
author	Yubao Liu Ligong Lu Haosheng Jin Xiaoming Chen Zhonglin Zhang Zaiyi Liu Changhong Liang
author_facet	Yubao Liu Ligong Lu Haosheng Jin Xiaoming Chen Zhonglin Zhang Zaiyi Liu Changhong Liang
author_sort	Yubao Liu
title	Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
title_short	Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
title_full	Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
title_fullStr	Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
title_full_unstemmed	Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.
title_sort	radiofrequency ablation of liver vx2 tumor: experimental results with mr diffusion-weighted imaging at 3.0t.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/edb997b4e70c4b0981a0b326e5f77f71
work_keys_str_mv	AT yubaoliu radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT ligonglu radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT haoshengjin radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT xiaomingchen radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT zhonglinzhang radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT zaiyiliu radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t AT changhongliang radiofrequencyablationoflivervx2tumorexperimentalresultswithmrdiffusionweightedimagingat30t
_version_	1718414255174189056

Radiofrequency ablation of liver VX2 tumor: experimental results with MR diffusion-weighted imaging at 3.0T.

Ejemplares similares