Grb2 binding induces phosphorylation-independent activation of Shp2

Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of receptor tyrosine kinases in response to differen...

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Autores principales:	Chi-Chuan Lin, Lukasz Wieteska, Kin Man Suen, Arnout P. Kalverda, Zamal Ahmed, John E. Ladbury
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c
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spelling	oai:doaj.org-article:edb9c4facda0446e8198cbaac3dd988c2021-12-02T13:27:04ZGrb2 binding induces phosphorylation-independent activation of Shp210.1038/s42003-021-01969-72399-3642https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01969-7https://doaj.org/toc/2399-3642Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of receptor tyrosine kinases in response to different cellular conditions. They find that cancer-related signalling in breast cancer cells can be attributed to the binding of Grb2 to Shp2.Chi-Chuan LinLukasz WieteskaKin Man SuenArnout P. KalverdaZamal AhmedJohn E. LadburyNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Chi-Chuan Lin Lukasz Wieteska Kin Man Suen Arnout P. Kalverda Zamal Ahmed John E. Ladbury Grb2 binding induces phosphorylation-independent activation of Shp2
description	Lin et al. investigate the interactions between adaptor protein, Grb2, and the ubiquitously expressed protein tyrosine phosphatase, Shp2. They find that monomeric Grb2 can activate Shp2 and its downstream signalling in the absence of up-regulation of receptor tyrosine kinases in response to different cellular conditions. They find that cancer-related signalling in breast cancer cells can be attributed to the binding of Grb2 to Shp2.
format	article
author	Chi-Chuan Lin Lukasz Wieteska Kin Man Suen Arnout P. Kalverda Zamal Ahmed John E. Ladbury
author_facet	Chi-Chuan Lin Lukasz Wieteska Kin Man Suen Arnout P. Kalverda Zamal Ahmed John E. Ladbury
author_sort	Chi-Chuan Lin
title	Grb2 binding induces phosphorylation-independent activation of Shp2
title_short	Grb2 binding induces phosphorylation-independent activation of Shp2
title_full	Grb2 binding induces phosphorylation-independent activation of Shp2
title_fullStr	Grb2 binding induces phosphorylation-independent activation of Shp2
title_full_unstemmed	Grb2 binding induces phosphorylation-independent activation of Shp2
title_sort	grb2 binding induces phosphorylation-independent activation of shp2
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edb9c4facda0446e8198cbaac3dd988c
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Grb2 binding induces phosphorylation-independent activation of Shp2

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