Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study

Abstract At present, no well-established biomarkers were ever found to distinguish unipolar depression and bipolar disorder (BD). This study aimed to provide a clearer comparison of UA levels between BD and major depressive disorder. Peripheral UA of 119 patients with BD in acute stage (AS) and 77 i...

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Autores principales:	Zhe Lu, Yingtan Wang, Guanglei Xun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/edbbab4a4ce8475b8be67cadc8793b56
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spelling	oai:doaj.org-article:edbbab4a4ce8475b8be67cadc8793b562021-12-02T17:23:46ZIndividuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study10.1038/s41598-021-97955-42045-2322https://doaj.org/article/edbbab4a4ce8475b8be67cadc8793b562021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97955-4https://doaj.org/toc/2045-2322Abstract At present, no well-established biomarkers were ever found to distinguish unipolar depression and bipolar disorder (BD). This study aimed to provide a clearer comparison of UA levels between BD and major depressive disorder. Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls. UA levels in BD group were higher than UD and HC groups regardless of the AS or RS, while differences in UA levels between UD group and HC group were not significant. Differences in UA levels of BD-M (bipolar mania/hypomania) were higher than BD-D (bipolar depression) subgroups, and UA levels of BD-M and BD-D subgroups were higher than UD and HC groups. The comparison of number of participants with hyperuricemia among groups confirmed the above results. There were no significant differences in UA levels of between drug-use and drug-free/naïve subgroups. UA could distinguish BD and UD significantly both in acute and remission stage. The study suggests patients with BD had a higher level of UA than UD, especially in mania episode. UA may be a potential biomarker to distinguish BD from UD.Zhe LuYingtan WangGuanglei XunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhe Lu Yingtan Wang Guanglei Xun Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
description	Abstract At present, no well-established biomarkers were ever found to distinguish unipolar depression and bipolar disorder (BD). This study aimed to provide a clearer comparison of UA levels between BD and major depressive disorder. Peripheral UA of 119 patients with BD in acute stage (AS) and 77 in remission stage (RS), and 95 patients with UD in AS and 61 in RS were measured, so were 180 healthy controls. UA levels in BD group were higher than UD and HC groups regardless of the AS or RS, while differences in UA levels between UD group and HC group were not significant. Differences in UA levels of BD-M (bipolar mania/hypomania) were higher than BD-D (bipolar depression) subgroups, and UA levels of BD-M and BD-D subgroups were higher than UD and HC groups. The comparison of number of participants with hyperuricemia among groups confirmed the above results. There were no significant differences in UA levels of between drug-use and drug-free/naïve subgroups. UA could distinguish BD and UD significantly both in acute and remission stage. The study suggests patients with BD had a higher level of UA than UD, especially in mania episode. UA may be a potential biomarker to distinguish BD from UD.
format	article
author	Zhe Lu Yingtan Wang Guanglei Xun
author_facet	Zhe Lu Yingtan Wang Guanglei Xun
author_sort	Zhe Lu
title	Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
title_short	Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
title_full	Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
title_fullStr	Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
title_full_unstemmed	Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
title_sort	individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/edbbab4a4ce8475b8be67cadc8793b56
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Individuals with bipolar disorder have a higher level of uric acid than major depressive disorder: a case–control study

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