A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan

The objective of the present research is to evaluate directly compressible chitosan-based tableting materials for the formulation of mucoadhesive matrix tablets intended for targeted drug release to distal segments of the GIT. The influence of sodium alginate, hypromellose, and silicified microcryst...

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Autores principales:	Jitka Muzikova, Eva Snejdrova, Juraj Martiska, Bara Doubkova, Andrea Veris
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chitosan matrix tablets silicified microcrystalline cellulose compressibility compactability mucoadhesion Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/edbc009ef7914956988e263485ed5d72
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spelling	oai:doaj.org-article:edbc009ef7914956988e263485ed5d722021-11-11T18:42:13ZA Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan10.3390/polym132136362073-4360https://doaj.org/article/edbc009ef7914956988e263485ed5d722021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/21/3636https://doaj.org/toc/2073-4360The objective of the present research is to evaluate directly compressible chitosan-based tableting materials for the formulation of mucoadhesive matrix tablets intended for targeted drug release to distal segments of the GIT. The influence of sodium alginate, hypromellose, and silicified microcrystalline cellulose (P90) on compressibility, compactability and lubricant sensitivity ratio was tested. Furthermore, the rheological properties of the hydrated surface layer of the matrix tablets and the mucoadhesion to a mucin substrate were analysed. Compressibility was evaluated using the energy profile of the compression process, compactability by means of the tensile strength of tablets, and lubricant sensitivity ratio was calculated to assess the sensitivity to lubricant. Addition of P90 to chitosan improved compressibility, which is demonstrated by the increase in the energy of plastic deformation and the higher tensile strength of tablets. P90 also significantly reduced the high lubricant sensitivity of chitosan. Presence of retarding components led to a decrease in Emax. All tested matrix tablets revealed a good mucoadhesion without a negative effect of P90 content. The viscosity of a gel layer on the surface of matrix tablets containing hypromellose was higher compared to those with sodium alginate. This was not reflected in the adhesive strength of the tablets. The formulated tableting materials combining chitosan and P90 are a suitable matrix for incorporation of an active ingredient, whose delayed release in the intestine can be achieved by the functionality of the chitosan-sodium alginate complex.Jitka MuzikovaEva SnejdrovaJuraj MartiskaBara DoubkovaAndrea VerisMDPI AGarticlechitosanmatrix tabletssilicified microcrystalline cellulosecompressibilitycompactabilitymucoadhesionOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3636, p 3636 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chitosan matrix tablets silicified microcrystalline cellulose compressibility compactability mucoadhesion Organic chemistry QD241-441
spellingShingle	chitosan matrix tablets silicified microcrystalline cellulose compressibility compactability mucoadhesion Organic chemistry QD241-441 Jitka Muzikova Eva Snejdrova Juraj Martiska Bara Doubkova Andrea Veris A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
description	The objective of the present research is to evaluate directly compressible chitosan-based tableting materials for the formulation of mucoadhesive matrix tablets intended for targeted drug release to distal segments of the GIT. The influence of sodium alginate, hypromellose, and silicified microcrystalline cellulose (P90) on compressibility, compactability and lubricant sensitivity ratio was tested. Furthermore, the rheological properties of the hydrated surface layer of the matrix tablets and the mucoadhesion to a mucin substrate were analysed. Compressibility was evaluated using the energy profile of the compression process, compactability by means of the tensile strength of tablets, and lubricant sensitivity ratio was calculated to assess the sensitivity to lubricant. Addition of P90 to chitosan improved compressibility, which is demonstrated by the increase in the energy of plastic deformation and the higher tensile strength of tablets. P90 also significantly reduced the high lubricant sensitivity of chitosan. Presence of retarding components led to a decrease in Emax. All tested matrix tablets revealed a good mucoadhesion without a negative effect of P90 content. The viscosity of a gel layer on the surface of matrix tablets containing hypromellose was higher compared to those with sodium alginate. This was not reflected in the adhesive strength of the tablets. The formulated tableting materials combining chitosan and P90 are a suitable matrix for incorporation of an active ingredient, whose delayed release in the intestine can be achieved by the functionality of the chitosan-sodium alginate complex.
format	article
author	Jitka Muzikova Eva Snejdrova Juraj Martiska Bara Doubkova Andrea Veris
author_facet	Jitka Muzikova Eva Snejdrova Juraj Martiska Bara Doubkova Andrea Veris
author_sort	Jitka Muzikova
title	A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
title_short	A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
title_full	A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
title_fullStr	A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
title_full_unstemmed	A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan
title_sort	study of compressibility, compactability and mucoadhesivity of tableting materials for matrix systems based on chitosan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/edbc009ef7914956988e263485ed5d72
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A Study of Compressibility, Compactability and Mucoadhesivity of Tableting Materials for Matrix Systems Based on Chitosan

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