Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several prote...

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Autores principales:	Stefano Guizzardi, Giuseppe Pedrazzi, Carlo Galli
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	tissue regeneration electromagnetic fields bone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/edc1ecac42a04fd58f2e38df482248da
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spelling	oai:doaj.org-article:edc1ecac42a04fd58f2e38df482248da2021-11-25T16:37:32ZLow Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues10.3390/app1122107582076-3417https://doaj.org/article/edc1ecac42a04fd58f2e38df482248da2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/10758https://doaj.org/toc/2076-3417Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several protein fractions with BMP- and TGF-β-like action. Activation of TGF-β signaling is required for EMD activity on cells and tissues, and a growing body of evidence indicates that EMD largely relies on this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as a tool to promote bone formation and osteoblast activity, and because recent studies have reported that the effects of EMFs on cells require primary cilia, by modulating the presence of membrane-bound receptors (e.g., for BMP) or signal mediators, it can be hypothesized that the application of EMFs may increase cell sensitivity to EMD: as TGFBR receptors have also been identified on primary cilia, EMFs could make cells more responsive to EMD by inducing the display of a higher number of receptors on the cellular membrane.Stefano GuizzardiGiuseppe PedrazziCarlo GalliMDPI AGarticletissue regenerationelectromagnetic fieldsboneTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 10758, p 10758 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	tissue regeneration electromagnetic fields bone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	tissue regeneration electromagnetic fields bone Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Stefano Guizzardi Giuseppe Pedrazzi Carlo Galli Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
description	Periodontal regeneration is a complex goal, which is commonly pursued with a combination of surgical techniques, biomaterials, and bioactive compounds. One such compound is enamel matrix derivative (EMD), a medical substance that is extracted from porcine tooth germs and which contains several protein fractions with BMP- and TGF-β-like action. Activation of TGF-β signaling is required for EMD activity on cells and tissues, and a growing body of evidence indicates that EMD largely relies on this pathway. As low frequency electromagnetic fields (EMFs) have long been investigated as a tool to promote bone formation and osteoblast activity, and because recent studies have reported that the effects of EMFs on cells require primary cilia, by modulating the presence of membrane-bound receptors (e.g., for BMP) or signal mediators, it can be hypothesized that the application of EMFs may increase cell sensitivity to EMD: as TGFBR receptors have also been identified on primary cilia, EMFs could make cells more responsive to EMD by inducing the display of a higher number of receptors on the cellular membrane.
format	article
author	Stefano Guizzardi Giuseppe Pedrazzi Carlo Galli
author_facet	Stefano Guizzardi Giuseppe Pedrazzi Carlo Galli
author_sort	Stefano Guizzardi
title	Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
title_short	Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
title_full	Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
title_fullStr	Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
title_full_unstemmed	Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues
title_sort	low frequency electromagnetic fields might increase the effect of enamel matrix derivative on periodontal tissues
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/edc1ecac42a04fd58f2e38df482248da
work_keys_str_mv	AT stefanoguizzardi lowfrequencyelectromagneticfieldsmightincreasetheeffectofenamelmatrixderivativeonperiodontaltissues AT giuseppepedrazzi lowfrequencyelectromagneticfieldsmightincreasetheeffectofenamelmatrixderivativeonperiodontaltissues AT carlogalli lowfrequencyelectromagneticfieldsmightincreasetheeffectofenamelmatrixderivativeonperiodontaltissues
_version_	1718413112381538304

Low Frequency Electromagnetic Fields Might Increase the Effect of Enamel Matrix Derivative on Periodontal Tissues

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