New Mitochondrial Targets in Fungal Pathogens

ABSTRACT In eukaryotic cells, mitochondria are responsible for the synthesis of ATP using power generated by the electron transport chain (ETC). While much of what is known about mitochondria has been gained from a study of a small number of model species, including the yeast Saccharomyces cerevisia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Daniel Murante, Deborah A. Hogan
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Candida albicans Candida species mitochondria Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/edc47fc3c75142d5ad5cf163f8348181
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:edc47fc3c75142d5ad5cf163f8348181
record_format	dspace
spelling	oai:doaj.org-article:edc47fc3c75142d5ad5cf163f83481812021-11-15T15:59:42ZNew Mitochondrial Targets in Fungal Pathogens10.1128/mBio.02258-192150-7511https://doaj.org/article/edc47fc3c75142d5ad5cf163f83481812019-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02258-19https://doaj.org/toc/2150-7511ABSTRACT In eukaryotic cells, mitochondria are responsible for the synthesis of ATP using power generated by the electron transport chain (ETC). While much of what is known about mitochondria has been gained from a study of a small number of model species, including the yeast Saccharomyces cerevisiae, the general mechanisms of mitochondrial respiration have been recognized as being highly conserved across eukaryotes. Now, Sun et al. (N. Sun, R. S. Parrish, R. A. Calderone, and W. A. Fonzi, mBio 10:e00300-19, 2019, https://doi.org/10.1128/mBio.00300-19) take the next steps in understanding mitochondrial function by identifying proteins that are unique to a smaller phylogenetic group of microbes. Using the combination of in silico, biochemical, and microbiological assays, Sun and colleagues identified seven genes that are unique to the CTG fungal clade, which contains multiple important human pathogens, including Candida albicans, and showed that they are required for full ETC function during respiratory metabolism. Because respiratory metabolism is critical for fungal pathogenesis, these clade-specific mitochondrial factors may represent novel therapeutic targets.Daniel MuranteDeborah A. HoganAmerican Society for MicrobiologyarticleCandida albicansCandida speciesmitochondriaMicrobiologyQR1-502ENmBio, Vol 10, Iss 5 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Candida albicans Candida species mitochondria Microbiology QR1-502
spellingShingle	Candida albicans Candida species mitochondria Microbiology QR1-502 Daniel Murante Deborah A. Hogan New Mitochondrial Targets in Fungal Pathogens
description	ABSTRACT In eukaryotic cells, mitochondria are responsible for the synthesis of ATP using power generated by the electron transport chain (ETC). While much of what is known about mitochondria has been gained from a study of a small number of model species, including the yeast Saccharomyces cerevisiae, the general mechanisms of mitochondrial respiration have been recognized as being highly conserved across eukaryotes. Now, Sun et al. (N. Sun, R. S. Parrish, R. A. Calderone, and W. A. Fonzi, mBio 10:e00300-19, 2019, https://doi.org/10.1128/mBio.00300-19) take the next steps in understanding mitochondrial function by identifying proteins that are unique to a smaller phylogenetic group of microbes. Using the combination of in silico, biochemical, and microbiological assays, Sun and colleagues identified seven genes that are unique to the CTG fungal clade, which contains multiple important human pathogens, including Candida albicans, and showed that they are required for full ETC function during respiratory metabolism. Because respiratory metabolism is critical for fungal pathogenesis, these clade-specific mitochondrial factors may represent novel therapeutic targets.
format	article
author	Daniel Murante Deborah A. Hogan
author_facet	Daniel Murante Deborah A. Hogan
author_sort	Daniel Murante
title	New Mitochondrial Targets in Fungal Pathogens
title_short	New Mitochondrial Targets in Fungal Pathogens
title_full	New Mitochondrial Targets in Fungal Pathogens
title_fullStr	New Mitochondrial Targets in Fungal Pathogens
title_full_unstemmed	New Mitochondrial Targets in Fungal Pathogens
title_sort	new mitochondrial targets in fungal pathogens
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/edc47fc3c75142d5ad5cf163f8348181
work_keys_str_mv	AT danielmurante newmitochondrialtargetsinfungalpathogens AT deborahahogan newmitochondrialtargetsinfungalpathogens
_version_	1718427003460255744

New Mitochondrial Targets in Fungal Pathogens

Ejemplares similares